Department of International Medical Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Int J Clin Pract. 2020 Jul;74(7):e13508. doi: 10.1111/ijcp.13508. Epub 2020 Apr 28.
Metabolic syndrome (MetS) is an independent risk factor for cardiovascular disease (CVD), in which platelet hyperactivation plays a pivotal role. The purpose of this study was to evaluate platelet function in MetS patients using Platelet Function Analyzer-100 (PFA-100) and to explore the risk factors for platelet hyperactivity in MetS.
We investigated participants who were enrolled for health check-up in our department. Routine physical examinations and fasting blood sample tests were performed when participants visited the hospital. MetS was defined as ≥3 of the risk factors according to the Harmonised criteria: central obesity, hypertension (HP), hypertriglyceridemia, low high density lipoprotein cholesterol and hyperglycaemia. Participants were divided into a MetS group (≥3), normal control (NC) group (0) and non-MetS group (1-2) according to the numbers of the five risk factors. Platelet function was tested by PFA-100, which measures the time taken for blood to occlude an aperture (closure time [CT]). All continuous data were compared using Student's t test or Mann-Whitney U test according to the data distribution. Categorical data were compared using the chi-square test. Logistic regression was used to investigate the independent risk marker for PFA-100 CT values.
A total of 831 participants (611 males and 220 females) was included in our subject. The MetS group had significantly shorter CT values compared with the NC group (106 (52-181) s vs 111 (70-210) s, P < .05) and the non-MetS Group (106 (52-181) s vs 113 (73-197) s, P < .05). Higher body mass index, hypertriglyceridemia and HP were correlated with shorter CT values (P < .05). Logistic regression analyses indicated that hypertriglyceridemia was an independent risk marker for shorter PFA-100 CT values (P < .05).
Our results indicate the presence of platelet hyperactivation in MetS patients and that hypertriglyceridemia is an independent risk marker for it. Triglyceride-lowering treatment may reduce CVD risk in MetS individuals.
代谢综合征（MetS）是心血管疾病（CVD）的独立危险因素，其中血小板过度激活起着关键作用。本研究旨在使用血小板功能分析仪-100（PFA-100）评估 MetS 患者的血小板功能，并探讨 MetS 中血小板过度活跃的危险因素。
我们调查了在我院进行健康检查的参与者。当参与者到医院就诊时，进行常规体格检查和空腹血样检测。MetS 根据协调标准定义为≥3 个危险因素：中心性肥胖、高血压（HP）、高甘油三酯血症、低高密度脂蛋白胆固醇和高血糖。根据五个危险因素的数量，参与者被分为 MetS 组（≥3）、正常对照组（0）和非 MetS 组（1-2）。通过 PFA-100 测量血液阻塞孔径所需的时间（闭塞时间[CT]）来测试血小板功能。根据数据分布，使用学生 t 检验或曼-惠特尼 U 检验比较所有连续数据。使用卡方检验比较分类数据。使用逻辑回归分析探讨 PFA-100 CT 值的独立风险标志物。
共纳入 831 名受试者（611 名男性和 220 名女性）。与 NC 组（106（52-181）s 比 111（70-210）s，P<.05）和非 MetS 组（106（52-181）s 比 113（73-197）s，P<.05）相比，MetS 组的 CT 值明显更短。更高的体重指数、高甘油三酯血症和 HP 与更短的 CT 值相关（P<.05）。逻辑回归分析表明，高甘油三酯血症是 PFA-100 CT 值较短的独立危险因素（P<.05）。
我们的研究结果表明 MetS 患者存在血小板过度激活，高甘油三酯血症是其独立危险因素。降低甘油三酯的治疗可能会降低 MetS 个体的 CVD 风险。
