Li Jiaxing, Zhou Lirong, Li Ben, Tian Rui, Hu Guangxin, Liu Zhijun
Department of Cardiovascular Medicine, Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University Yinchuan, Ningxia, China.
Department of Internal Medicine, School of Clinical Medicine, Ningxia Medical University Yinchuan, Ningxia, China.
Am J Transl Res. 2025 Mar 15;17(3):1803-1813. doi: 10.62347/MXEJ5508. eCollection 2025.
Metabolic syndrome (MS) is a cluster of metabolic disorders characterized by damage to multiple organs. Platelet distribution width (PDW) has been used to assess the progression of several metabolic disorders, including left ventricular hypertrophy (LVH) and diabetic nephropathy (DN). Therefore, this study aimed to evaluate the predictive value of PDW in relation to organ damage in patients with MS.
The study included 151 patients with MS and 113 healthy controls. Clinicopathological data, including sex, age, abdominal circumference, blood pressure, and body mass index (BMI), were collected. The predictive potential of PDW was assessed by analyzing its correlation with MS progression, LVH, atherosclerosis, and kidney function.
The analysis revealed that patients in the MS group had higher levels of BMI, abdominal circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), and fasting plasma glucose (FPG), and lower levels of high-density lipoprotein cholesterol (HDL-C), compared with controls. PDW was positively correlated with BMI, abdominal circumference, SBP, DBP, and FPG, and negatively correlated with HDL-C. FPG, SBP, and HDL-C were identified as independent parameters contributing to changes in PDW. Furthermore, heart function was positively related to PDW levels, while kidney function was negatively related. Logistic regression analysis further demonstrated that PDW was an independent risk factor for LVH, atherosclerosis, and kidney dysfunction.
PDW could serve as a promising predictive indicator for organ damage associated with the progression of MS.
代谢综合征（MS）是一组以多器官损害为特征的代谢紊乱症。血小板分布宽度（PDW）已被用于评估包括左心室肥厚（LVH）和糖尿病肾病（DN）在内的多种代谢紊乱的进展情况。因此，本研究旨在评估PDW对MS患者器官损害的预测价值。
该研究纳入了151例MS患者和113例健康对照者。收集了临床病理数据，包括性别、年龄、腹围、血压和体重指数（BMI）。通过分析PDW与MS进展、LVH、动脉粥样硬化和肾功能的相关性来评估其预测潜力。
分析显示，与对照组相比，MS组患者的BMI、腹围、收缩压（SBP）、舒张压（DBP）、甘油三酯（TG）和空腹血糖（FPG）水平较高，而高密度脂蛋白胆固醇（HDL-C）水平较低。PDW与BMI、腹围、SBP、DBP和FPG呈正相关，与HDL-C呈负相关。FPG、SBP和HDL-C被确定为导致PDW变化的独立参数。此外，心功能与PDW水平呈正相关，而肾功能与PDW水平呈负相关。逻辑回归分析进一步表明，PDW是LVH、动脉粥样硬化和肾功能不全的独立危险因素。
PDW可能是MS进展相关器官损害的一个有前景的预测指标。
