Computational Science Lab, Faculty of Science, Institute for Informatics, University of Amsterdam, Amsterdam, Netherlands.
Department of Hydrodynamic Systems, Budapest University of Technology and Economics, Budapest, Hungary.
Int J Numer Method Biomed Eng. 2020 Jun;36(6):e3340. doi: 10.1002/cnm.3340. Epub 2020 Apr 17.
Virtual flow diverter deployment techniques underwent significant development during the last couple of years. Each existing technique displays advantageous features, as well as significant limitations. One common drawback is the lack of quantitative validation of the mechanics of the device. In the following work, we present a new spring-mass-based method with validated mechanical responses that combines many of the useful capabilities of previous techniques. The structure of the virtual braids naturally incorporates the axial length changes as a function of the local expansion diameter. The force response of the model was calibrated using the measured response of real FDs. The mechanics of the model allows to replicate the expansion process during deployment, including additional effects such as the push-pull technique that is required for the deployment of braided FDs to achieve full opening and proper wall apposition. Furthermore, it is a computationally highly efficient solution that requires little pre-processing and has a run-time of a few seconds on a general laptop and thus allows for exploratory analyses. The model was applied in a patient-specific geometry, where corresponding accurate control measurements in a 3D-printed model were also available. The analysis shows the effects of FD oversizing and push-pull application on the radial expansion, surface density, and on the wall contact pressure.
虚拟血流分流器部署技术在过去几年中经历了重大发展。每种现有技术都具有优势特征,同时也存在显著的局限性。一个共同的缺点是缺乏对设备力学性能的定量验证。在接下来的工作中,我们提出了一种新的基于弹簧质量的方法,该方法具有经过验证的机械响应,结合了许多以前技术的有用功能。虚拟编织结构自然包含了轴向长度随局部扩张直径变化的关系。模型的力响应是使用真实 FD 的测量响应进行校准的。该模型的力学特性允许复制部署过程中的扩张过程,包括额外的效果,如推挽技术,这对于部署编织 FD 以实现完全打开和适当的壁贴附是必需的。此外,它是一种计算效率非常高的解决方案,几乎不需要预处理,并且在普通笔记本电脑上的运行时间为几秒钟,因此允许进行探索性分析。该模型应用于特定于患者的几何形状,其中还提供了在 3D 打印模型中进行相应准确控制测量的结果。分析表明了 FD 过大和推挽应用对径向扩张、表面密度以及壁面接触压力的影响。