电化学氢碘酸介导的分子间碳氮键形成反应：由芳基酮和苄胺合成咪唑
Electrochemical HI-mediated Intermolecular C-N Bond Formation to Synthesize Imidazoles from Aryl Ketones and Benzylamines.
作者信息
Yang Zan, Zhang Jiaqi, Hu Liping, Li An, Li Lijun, Liu Kun, Yang Tao, Zhou Congshan
机构信息
College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, China.
出版信息
J Org Chem. 2020 May 1;85(9):5952-5958. doi: 10.1021/acs.joc.0c00316. Epub 2020 Apr 20.
An efficient and novel electrochemical oxidative tandem cyclization of aryl ketones and benzylamines for the synthesis of 1,2,4-trisubstituted-(1)-imidazoles has been developed under metal- and oxidant-free conditions. This direct C-N bond formation strategy, with a broad functional group tolerance, affords the desired imidazoles in moderate to excellent yields.
在无金属和无氧化剂的条件下，开发了一种高效且新颖的芳基酮和苄胺的电化学氧化串联环化反应，用于合成1,2,4-三取代-(1)-咪唑。这种直接形成C-N键的策略具有广泛的官能团耐受性，能以中等至优异的产率得到所需的咪唑。
Zotero 插件