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Beneficial opioid management strategies: A review of the evidence for the use of opioid treatment agreements.有益的阿片类药物管理策略:阿片类药物治疗协议使用证据的综述。
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2
Mortality After Discontinuation of Primary Care-Based Chronic Opioid Therapy for Pain: a Retrospective Cohort Study.基于初级保健的慢性阿片类药物治疗疼痛后停药的死亡率:一项回顾性队列研究。
J Gen Intern Med. 2019 Dec;34(12):2749-2755. doi: 10.1007/s11606-019-05301-2. Epub 2019 Aug 29.
3
Opioid Taper Is Associated with Subsequent Termination of Care: a Retrospective Cohort Study.阿片类药物减量与后续护理终止相关:一项回顾性队列研究。
J Gen Intern Med. 2020 Jan;35(1):36-42. doi: 10.1007/s11606-019-05227-9. Epub 2019 Aug 19.
4
Rates of Physician Coprescribing of Opioids and Benzodiazepines After the Release of the Centers for Disease Control and Prevention Guidelines in 2016.2016 年疾病预防控制中心发布指南后,医生同时开处阿片类药物和苯二氮䓬类药物的比率。
JAMA Netw Open. 2019 Aug 2;2(8):e198325. doi: 10.1001/jamanetworkopen.2019.8325.
5
Loperamide: A Readily Available but Dangerous Opioid Substitute.洛哌丁胺:一种易得但危险的阿片类替代品。
J Clin Pharmacol. 2019 Sep;59(9):1165-1169. doi: 10.1002/jcph.1449. Epub 2019 May 22.
6
Challenges with Implementing the Centers for Disease Control and Prevention Opioid Guideline: A Consensus Panel Report.实施疾病预防控制中心阿片类药物指南的挑战:共识小组报告。
Pain Med. 2019 Apr 1;20(4):724-735. doi: 10.1093/pm/pny307.
7
Does Opioid Tapering in Chronic Pain Patients Result in Improved Pain or Same Pain vs Increased Pain at Taper Completion? A Structured Evidence-Based Systematic Review.慢性疼痛患者的阿片类药物逐渐减量是否会导致疼痛改善或与减量完成时的疼痛相同,还是会增加疼痛?一项基于结构化证据的系统综述。
Pain Med. 2019 Nov 1;20(11):2179-2197. doi: 10.1093/pm/pny231.
8
Safety and Efficacy of Lofexidine for Medically Managed Opioid Withdrawal: A Randomized Controlled Clinical Trial.盐酸可乐定治疗阿片类药物戒断的安全性和疗效:一项随机对照临床试验。
J Addict Med. 2019 May/Jun;13(3):169-176. doi: 10.1097/ADM.0000000000000474.
9
CAREFUL: A Practical Guide for Improving the Clinical Surveillance of Long-Term Opioid Therapy.《谨慎:改善长期阿片类药物治疗临床监测实用指南》
Mayo Clin Proc. 2018 Aug;93(8):1149. doi: 10.1016/j.mayocp.2018.05.017.
10
Opioid-Induced Adrenal Insufficiency.阿片类药物引起的肾上腺功能不全。
Mayo Clin Proc. 2018 Jul;93(7):937-944. doi: 10.1016/j.mayocp.2018.04.010.

阿片类药物管理:起始、监测与减量

Opioid Management: Initiating, Monitoring, and Tapering.

作者信息

Hooten W Michael

机构信息

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Charlton 1-145, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

Phys Med Rehabil Clin N Am. 2020 May;31(2):265-277. doi: 10.1016/j.pmr.2020.01.006. Epub 2020 Mar 11.

DOI:10.1016/j.pmr.2020.01.006
PMID:32279729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7156434/
Abstract

Numerous guidelines targeting safe use of opioids for chronic pain have been published but substantial challenges persist in clinical application of best practice recommendations. This article describes a pragmatic approach to clinical care of adults with chronic pain receiving long-term opioid therapy. Three components of care are emphasized: (1) medical and mental health assessment before initiating opioid therapy, (2) clinical surveillance during the course of long-term opioid therapy, and (3) clinical considerations and strategies governing opioid tapering. A pressing need exists for ongoing research to further clarify the optimal role that long-term opioid therapy has in treatment of chronic pain.

摘要

针对慢性疼痛安全使用阿片类药物的众多指南已发布,但在最佳实践建议的临床应用中仍存在重大挑战。本文描述了一种针对接受长期阿片类药物治疗的慢性疼痛成人患者的务实临床护理方法。强调了护理的三个组成部分:(1)开始阿片类药物治疗前的医学和心理健康评估,(2)长期阿片类药物治疗过程中的临床监测,以及(3)指导阿片类药物减量的临床考虑因素和策略。迫切需要进行持续研究,以进一步阐明长期阿片类药物治疗在慢性疼痛治疗中的最佳作用。