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本文引用的文献

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Trends and Rapidity of Dose Tapering Among Patients Prescribed Long-term Opioid Therapy, 2008-2017.2008-2017 年长期阿片类药物治疗患者的剂量逐渐减少趋势和速度。
JAMA Netw Open. 2019 Nov 1;2(11):e1916271. doi: 10.1001/jamanetworkopen.2019.16271.
2
Mortality After Discontinuation of Primary Care-Based Chronic Opioid Therapy for Pain: a Retrospective Cohort Study.基于初级保健的慢性阿片类药物治疗疼痛后停药的死亡率:一项回顾性队列研究。
J Gen Intern Med. 2019 Dec;34(12):2749-2755. doi: 10.1007/s11606-019-05301-2. Epub 2019 Aug 29.
3
Opioid Taper Is Associated with Subsequent Termination of Care: a Retrospective Cohort Study.阿片类药物减量与后续护理终止相关:一项回顾性队列研究。
J Gen Intern Med. 2020 Jan;35(1):36-42. doi: 10.1007/s11606-019-05227-9. Epub 2019 Aug 19.
4
Access to Primary Care Clinics for Patients With Chronic Pain Receiving Opioids.慢性疼痛接受阿片类药物治疗的患者获得初级保健诊所的途径。
JAMA Netw Open. 2019 Jul 3;2(7):e196928. doi: 10.1001/jamanetworkopen.2019.6928.
5
Opioid medication discontinuation and risk of adverse opioid-related health care events.阿片类药物停药与不良阿片类药物相关医疗事件风险。
J Subst Abuse Treat. 2019 Aug;103:58-63. doi: 10.1016/j.jsat.2019.05.001. Epub 2019 May 5.
6
No Shortcuts to Safer Opioid Prescribing.安全开具阿片类药物处方没有捷径可走。
N Engl J Med. 2019 Jun 13;380(24):2285-2287. doi: 10.1056/NEJMp1904190. Epub 2019 Apr 24.
7
Association Between Opioid Dose Variability and Opioid Overdose Among Adults Prescribed Long-term Opioid Therapy.长期阿片类药物治疗患者的阿片类药物剂量变异性与阿片类药物过量之间的关联。
JAMA Netw Open. 2019 Apr 5;2(4):e192613. doi: 10.1001/jamanetworkopen.2019.2613.
8
Initial Opioid Prescriptions among U.S. Commercially Insured Patients, 2012-2017.2012-2017 年美国商业保险患者初始阿片类药物处方情况。
N Engl J Med. 2019 Mar 14;380(11):1043-1052. doi: 10.1056/NEJMsa1807069.
9
Challenges with Implementing the Centers for Disease Control and Prevention Opioid Guideline: A Consensus Panel Report.实施疾病预防控制中心阿片类药物指南的挑战:共识小组报告。
Pain Med. 2019 Apr 1;20(4):724-735. doi: 10.1093/pm/pny307.
10
Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis.慢性非癌痛阿片类药物治疗:系统评价和荟萃分析。
JAMA. 2018 Dec 18;320(23):2448-2460. doi: 10.1001/jama.2018.18472.

非自愿剂量削减命令在临床或伦理上都是没有道理的:分析。

Nonconsensual Dose Reduction Mandates are Not Justified Clinically or Ethically: An Analysis.

机构信息

Stefan G. Kertesz, M.D., M.Sc., is a professor at the Department of Medicine, UAB School of Medicine and research investigator at the Birmingham VA Medical Center. He is a board-certified internal medicine (American Board of Internal Medicine) and addiction medicine physician (American Board of Addiction Medicine). His research career began in 2000 and he has been funded by both the National Institute on Drug Abuse and the Health Services Research & Development Branch of the Department of Veterans Affairs. He received his MD from Harvard Medical School in Boston, MA and his MSc from Boston University School of Public Health in Boston, MA. Ajay Manhapra, M.D., is Lecturer at Yale School of Medicine in the Department of Psychiatry, Assistant Professor, at the Eastern Virginia Medical School in the Department of Physical Medicine and Rehabilitation and Psychiatry, and Research Scientist at the VA New England Mental Illness Research, Education and Clinical Center. Dr. Manhapra is a board-certified Internist and Addiction Medicine physician with educational, clinical and research focus on pain and addiction. He runs a unique clinic for recovering patients with severe disabling chronic pain and medication or substance dependence at Hampton VA Medical Center, where he is developing an interdisciplinary integrative model for treatment of pain and addiction. Dr. Manhapra received his medical degree from Government Medical College, Thrissur, Kerala, India, and completed his Addiction Medicine fellowship at Yale School of Medicine. Adam J. Gordon, M.D., M.P.H., is Professor of Medicine and Psychiatry at the University of Utah School of Medicine, Director of the Program for Addiction Research, Clinical Care, Knowledge, and Advocacy (PARCKA), and Chief of Addiction Medicine at VA Salt Lake City Health Care System and. He is a board-certified internal medicine (American Board of Internal Medicine) and addiction medicine physician (American Board of Preventive Medicine) with a 20-year track record of conducting research on the quality, equity, and efficiency of health care for vulnerable populations (e.g., persons with opioid use disorders, persons who are homeless, persons with hazardous alcohol use and other addiction disorders). He received his MD from University of Pittsburgh School of Medicine in Pittsburgh, PA and his MPH from the University of Pittsburgh Graduate School of Public Health in Pittsburgh, PA.

出版信息

J Law Med Ethics. 2020 Jun;48(2):259-267. doi: 10.1177/1073110520935337.

DOI:10.1177/1073110520935337
PMID:32631183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7938366/
Abstract

This manuscript describes the institutional and clinical considerations that apply to the question of whether to mandate opioid dose reduction in patients who have received opioids long-term. It describes how a calamitous rise in addiction and overdose involving opioids has both led to a clinical recalibration by healthcare providers, and to strong incentives favoring forcible opioid reduction by policy making agencies. Neither the 2016 Guideline issued by the Centers for Disease Control and Prevention nor clinical evidence can justify or promote such policies as safe or effective.

摘要

这篇手稿描述了适用于长期接受阿片类药物治疗的患者是否需要强制减少阿片类药物剂量这一问题的机构和临床方面的考虑因素。它描述了阿片类药物成瘾和过量的灾难性上升如何导致医疗保健提供者进行临床重新调整,并促使政策制定机构大力支持强制减少阿片类药物。疾病控制与预防中心发布的 2016 年指南和临床证据都不能证明这些政策是安全或有效的。