School of Materials Science and Engineering, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
School of Materials Science and Engineering, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110789. doi: 10.1016/j.msec.2020.110789. Epub 2020 Feb 29.
Polydimethylsiloxane (PDMS) film with significantly enhanced water permeability and uptake was prepared by incorporating spherical elastic hollow microcapsules (eHMCs) in it. eHMCs were prepared through O/W/O emulsification method. Water permeability and uptake of the film increased significantly in proportion to the amount of embedded eHMCs while minimizing the changes in elastic characteristics and transparency of PDMS. The release rate of loaded water soluble model drug from the eHMC-embedded PDMS film could be controlled by the magnitude of uniaxial mechanical stimulus applied over the film and initial drug loading amount, with negligible release of drug from the film in the absence of external stimulation. Thus, these biocompatible and elastic composite PDMS films are potentially useful, including as an easily accessible and instantly effective way of controlling hydrophilic drug release using the mechanical stimulus as well as a soft elastomer with enhanced water uptake and permeability.
通过在其中掺入球形弹性空心微胶囊（eHMC），制备了具有显著增强的水透过率和吸水性的聚二甲基硅氧烷（PDMS）薄膜。eHMC 通过 O/W/O 乳化方法制备。薄膜的水透过率和吸水性随着嵌入的 eHMC 数量的增加而显著增加，同时最小化了 PDMS 的弹性特性和透明度的变化。从嵌入 eHMC 的 PDMS 薄膜中释放的负载水溶性模型药物的速率可以通过施加在薄膜上的单轴机械刺激的大小和初始药物负载量来控制，在没有外部刺激的情况下，药物从薄膜中的释放可以忽略不计。因此，这些具有生物相容性和弹性的复合 PDMS 薄膜具有潜在的用途，包括作为一种简单易用且即时有效的方法，使用机械刺激来控制亲水性药物的释放，以及作为一种具有增强吸水性和透过性的软弹性体。
