Li L C, Vu N T
College of Pharmacy, University of Oklahoma, Oklahoma City 73190, USA.
J Pharm Pharmacol. 1995 Jun;47(6):447-50. doi: 10.1111/j.2042-7158.1995.tb05827.x.
A silicone elastomer latex was evaluated as a topical drug-delivery system. With the addition of a fumed silica and the removal of water, the latex produced elastomeric solid films. The water vapour permeability of the solid film was found to be a function of the film composition. An increase in silica content and the incorporation of a water-soluble component, PEG 3350, rendered the silicone elastomer-free film even more permeable to water vapour. The release of hydrocortisone from the elastomer film can be described by a matrix-diffusion-controlled mechanism. Drug diffusion is thought to occur through the hydrophobic silicone polymer network and the hydrated hydrophilic silica region in the film matrix. Silicone elastomer film with a higher silica content exhibited a faster drug-release rate. The addition of PEG 3350 to the film further enhanced the drug-release rate.
一种有机硅弹性体乳胶被评估为一种局部给药系统。通过添加气相法二氧化硅并去除水分，乳胶制成了弹性体固体薄膜。发现固体薄膜的水蒸气透过率是薄膜组成的函数。二氧化硅含量的增加以及水溶性成分聚乙二醇3350的加入，使不含有机硅弹性体的薄膜对水蒸气的渗透性更强。氢化可的松从弹性体薄膜中的释放可以用基质扩散控制机制来描述。药物扩散被认为是通过薄膜基质中的疏水性有机硅聚合物网络和水合亲水性二氧化硅区域发生的。二氧化硅含量较高的有机硅弹性体薄膜表现出更快的药物释放速率。向薄膜中添加聚乙二醇3350进一步提高了药物释放速率。
