将冷等离体等离子体与 3D 打印的生物活性纳米复合支架相结合，用于软骨再生。
Integrating cold atmospheric plasma with 3D printed bioactive nanocomposite scaffold for cartilage regeneration.
机构信息
Department of Mechanical and Aerospace Engineering, The George Washington University, DC 20052, USA.
Department of Mechanical and Aerospace Engineering, The George Washington University, DC 20052, USA; Department of Electrical and Computer Engineering, The George Washington University, DC 20052, USA; Department of Biomedical Engineering, The George Washington University, DC 20052, USA; Department of Medicine, The George Washington University, DC 20052, USA.
出版信息
Mater Sci Eng C Mater Biol Appl. 2020 Jun;111:110844. doi: 10.1016/j.msec.2020.110844. Epub 2020 Mar 13.
The progressive degeneration of articular cartilage or osteoarthritis of the knee is a serious clinical problem affecting patient quality of life. In recent years, artificially engineered cartilage scaffolds have been widely studied as a promising method to stimulate cartilage regeneration. In this study, a novel biomimetic cartilage scaffold was developed by integrating a cold atmospheric plasma (CAP) treatment with prolonged release of bioactive factors. Specifically, a surface of 3D printed hydrogel scaffold with drug-loaded nanoparticles was treated with CAP. Our results showed that the scaffolds with CAP treatment can improve hydrophilicity as well as surface nano-roughness and can thus facilitate stem cell adhesion. More importantly, this study demonstrated that integrating CAP treatment with drug-loaded nanoparticles can synergistically enhance chondrogenesis of human bone marrow mesenchymal stem cells when compared to control scaffolds. The results in this study indicate the great potential of applying CAP and drug-loaded nanoparticles into 3D printed tissue scaffolds for promoting cartilage regeneration.
膝关节的关节软骨进行性退变或骨关节炎是一个严重的临床问题，影响患者的生活质量。近年来，人工工程软骨支架作为一种刺激软骨再生的有前途的方法得到了广泛的研究。在这项研究中，通过整合冷等离子体（CAP）处理和生物活性因子的缓释，开发了一种新型仿生软骨支架。具体来说，用 CAP 处理载药纳米颗粒的 3D 打印水凝胶支架的表面。我们的结果表明，经过 CAP 处理的支架可以提高亲水性和表面纳米粗糙度，从而促进干细胞的黏附。更重要的是，这项研究表明，与对照支架相比，将 CAP 处理与载药纳米颗粒相结合可以协同增强人骨髓间充质干细胞的软骨生成。这项研究的结果表明，将 CAP 和载药纳米颗粒应用于 3D 打印组织支架中促进软骨再生具有巨大的潜力。
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