Facchinetti F, Borella P, Valentini M, Fioroni L, Genazzani A R
Department of Obstetrics and Gynecology, University of Modena, Italy.
Gynecol Endocrinol. 1988 Sep;2(3):249-56. doi: 10.3109/09513599809029349.
Intracellular magnesium (Mg) levels regulate several enzymatic reactions and the hypoactivity of Mg has been involved in different pathological states. In addition to other factors, gonadal hormones, too, have been found to interfere in Mg balance. This study evaluates the changes in Mg in women throughout the normal menstrual cycle and those measured at weekly intervals in males. Magnesium and potassium (K) levels were measured in the plasma, red blood cells (RBC), lymphocytes (LC) and polymorphonucleated cells (PMN) of 11 normal menstruating women, in different periods of their menstrual cycle. Blood samples were collected every 4th day. According to the time and LH, progesterone and estradiol levels, they were classed as follicular (Foll), periovulatory (OV), luteal (Lut) or premenstrual (PM). The Menstrual Distress Questionnaire completed by the subjects revealed that no significant symptomatology was present. Four blood samples were also collected from 4 normal males, at weekly intervals. Mg and K were determined by atomic absorption spectrophotometry. LC and PMN were purified by centrifugation on a Ficoll discontinuous gradient. No differences were found in males versus females in the Mg or K contents in the different compartments. In the 4 periods tested, the K levels were constant, in both females and males. The same applies for Mg contents in males. In females, Mg contents, as well as the Mg/K ratio in LC and PMN, showed a significant increase in the premenstrual period compared with the other periods of the cycle. On the contrary, plasma and RBC Mg levels were constant throughout the cycle.(ABSTRACT TRUNCATED AT 250 WORDS)
细胞内镁（Mg）水平调节多种酶促反应，镁活性降低与不同病理状态有关。除其他因素外，还发现性腺激素会干扰镁平衡。本研究评估了正常月经周期女性体内镁的变化，以及男性每周测量一次的镁变化情况。对11名正常月经周期女性在其月经周期的不同阶段，采集血浆、红细胞（RBC）、淋巴细胞（LC）和多形核细胞（PMN）样本，检测镁和钾（K）水平。每4天采集一次血样。根据时间以及促黄体生成素、孕酮和雌二醇水平，将其分为卵泡期（Foll）、围排卵期（OV）、黄体期（Lut）或经前期（PM）。受试者填写的月经困扰问卷显示无明显症状。还从4名正常男性中每周采集一次血样，共采集4次。通过原子吸收分光光度法测定镁和钾。通过在Ficoll不连续梯度上离心纯化LC和PMN。在不同区室中，男性和女性的镁或钾含量没有差异。在测试的4个时期中，女性和男性的钾水平均保持恒定。男性的镁含量也是如此。在女性中，与月经周期的其他时期相比，经前期LC和PMN中的镁含量以及镁/钾比值显著增加。相反，整个周期中血浆和RBC中的镁水平保持恒定。（摘要截短于250字）
