Deuster P A, Dolev E, Bernier L L, Trostmann U H
Department of Military Medicine, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, MD 20814-4799.
Am J Obstet Gynecol. 1987 Oct;157(4 Pt 1):964-8. doi: 10.1016/s0002-9378(87)80096-0.
The effect of menstrual cycle phases on the indexes of magnesium and zinc status was assessed in five normally menstruating women. Plasma concentrations of magnesium and zinc and the magnesium and zinc content of red blood cells and peripheral blood mononuclear cells were measured for 3 or 5 days per week during three menstrual cycles. The cycles were divided into four phases: menses, follicular, ovulatory, and luteal. Plasma magnesium concentrations were highest during menses and then gradually declined, reaching the lowest point during the ovulatory phase. This was followed by a rise during the luteal phase. Plasma zinc concentrations were higher during menses and the follicular phase and then dropped during the ovulatory and luteal phases. Both the magnesium and zinc content of red blood cells and mononuclear cells remained constant over the course of the study and did not change significantly as a function of cycle phase. This study provides evidence that plasma magnesium and zinc concentrations fluctuate during the menstrual cycle in a phase-related fashion in normally menstruating women. Whether these changes are hormonally mediated or reflect metabolic changes will require further study.
在五名月经周期正常的女性中评估了月经周期各阶段对镁和锌状态指标的影响。在三个月经周期中，每周测量3天或5天的血浆镁和锌浓度以及红细胞和外周血单核细胞中的镁和锌含量。月经周期分为四个阶段：月经期、卵泡期、排卵期和黄体期。血浆镁浓度在月经期最高，然后逐渐下降，在排卵期达到最低点。随后在黄体期上升。血浆锌浓度在月经期和卵泡期较高，然后在排卵期和黄体期下降。在研究过程中，红细胞和单核细胞中的镁和锌含量保持恒定，并且不会随着周期阶段的变化而发生显著变化。这项研究提供了证据，表明在月经周期正常的女性中，血浆镁和锌浓度会以与阶段相关的方式波动。这些变化是由激素介导的还是反映了代谢变化，还需要进一步研究。
