Numoto Shingo, Kurahashi Hirokazu, Iwayama Hideyuki, Okumura Akihisa
Department of Pediatrics, Aichi Medical University, Nagakute, Aichi, Japan; Department of Pediatrics, Daiyukai General Hospital, Ichinomiya, Aichi, Japan.
Department of Pediatrics, Aichi Medical University, Nagakute, Aichi, Japan.
Brain Dev. 2020 Aug;42(7):551-554. doi: 10.1016/j.braindev.2020.03.006. Epub 2020 Apr 9.
Benign convulsions with gastroenteritis are characterized by a cluster of seizures. Sodium channel blockers are efficacious. We prescribed lacosamide, a new channel blocker, for five patients. Patient age ranged from 17 to 33 months; all five experienced 1-4 generalized convulsions persisting for 30-120 s. One patient exhibited a transient splenial lesion on head magnetic resonance imaging. All received one dose (2 mg/kg) of lacosamide. The convulsions ceased, and no adverse drug effect was noted. A single dose of lacosamide was effective and well-tolerated in five patients with benign convulsions with gastroenteritis.
伴有肠胃炎的良性惊厥以一连串癫痫发作为特征。钠通道阻滞剂有效。我们给5名患者开了一种新型通道阻滞剂拉科酰胺。患者年龄在17至33个月之间；所有5名患者都经历了1至4次全身性惊厥，持续30至120秒。一名患者头部磁共振成像显示有一过性胼胝体病变。所有患者均接受了一剂（2mg/kg）拉科酰胺。惊厥停止，未观察到药物不良反应。一剂拉科酰胺对5名伴有肠胃炎的良性惊厥患者有效且耐受性良好。
