Ribeiro J K C, Nascimento T V, Agostinho A G, Freitas R M, Santos L H P, Machado L M Q, Leal-Cardoso J H, Moreira-Gomes M D, Ceccatto V M
Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.
Diabetes Metab Syndr Obes. 2020 Apr 1;13:991-1004. doi: 10.2147/DMSO.S225160. eCollection 2020.
Diabetes mellitus is a syndrome with multiple etiologies involving insulin, in which there is a lack of production and/or loss of sensitivity to this hormone resulting in insulin resistance. Treatment and control of this disease requires changes in diet, use of medication, and lifestyle, such as physical activity. These modifications may compromise quality-of-life if there is no proper guidance for the treatment or alert to possible complications caused by the disease.
This study aimed to evaluate biochemical and hematological parameters, and to assess brain derived neurotrophic factor levels in diabetic Wistar rats submitted to chronic physical exercise.
The results demonstrated an increase in plasma concentration of brain-derived neurotrophic factor (BDNF) in association with hyperglycemia reduction in diabetic animals.
The results obtained suggest that there is a regulation of glucose homeostasis between peripheral tissues and the central nervous system. Exercise-induced BDNF also improved levels of glycemia, body weight, and dyslipidemia. In hematological evaluation, BDNF increase was positively correlated with an improvement in leukocyte parameters. Electrophoresis analyses demonstrated a reduction in levels of pro-inflammatory proteins, lipoprotein fractions, and albumin preservation in diabetic animals trained with elevated concentration of plasma BDNF.
In conclusion, this study demonstrated that chronic exercise was able to elevate BDNF levels in plasma, which resulted directly in positive hypoglycemic activity in diabetic animals and a reduction of the metabolic syndrome associated with diabetes mellitus.
糖尿病是一种涉及胰岛素的多病因综合征，其特征是胰岛素分泌不足和/或对该激素的敏感性丧失，从而导致胰岛素抵抗。该疾病的治疗和控制需要饮食调整、药物使用以及生活方式的改变，如体育锻炼。如果在治疗过程中没有适当的指导或对疾病可能引起的并发症缺乏警惕，这些改变可能会影响生活质量。
本研究旨在评估慢性体育锻炼对糖尿病Wistar大鼠生化和血液学参数的影响，并评估脑源性神经营养因子水平。
结果表明，糖尿病动物血浆中脑源性神经营养因子（BDNF）浓度升高，同时血糖降低。
所得结果表明，外周组织和中枢神经系统之间存在葡萄糖稳态调节。运动诱导的BDNF还改善了血糖水平、体重和血脂异常。在血液学评估中，BDNF的增加与白细胞参数的改善呈正相关。电泳分析表明，血浆BDNF浓度升高的训练糖尿病动物中，促炎蛋白水平降低，脂蛋白组分减少，白蛋白保持不变。
总之，本研究表明，慢性运动能够提高血浆中BDNF水平，这直接导致糖尿病动物出现积极的降血糖活性，并减少与糖尿病相关的代谢综合征。
