Mahgoub Marwa Yahia, Abou Ghanima Ahmed Taha, Elmohamady Mohamed Nagy, Abdul Basset Shaza
Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Benha University, Benha, Egypt.
Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt.
Open Access Rheumatol. 2020 Mar 30;12:35-40. doi: 10.2147/OARRR.S244838. eCollection 2020.
Both primary osteoarthritis (OA) and age-related macular degeneration (AMD) cause disability in old people. This study aimed to detect the relation between primary osteoarthritis and age-related macular degeneration in a sample of geriatric Egyptian population.
This cross-sectional study included 222 primary OA patients. Medical history, musculoskeletal examination, body mass index (BMI) calculation, and ophthalmological examination, radiographs of anteroposterior view and weight-bearing position for both hips and both knees and posteroanterior view for hands, Kellgren and Lawrence grading score for radiological severity of OA, optical coherence tomography (OCT), and fundus fluorescence angiography FFA for evaluation of the macula were done. AMD was classified into early, intermediate, and late. The collected data were analyzed using SPSS version 25.0.
Forty-six OA patients had AMD [19 cases had early, 15 cases had intermediate and 12 cases with late (7 neovascular (NV) and 5 geographic atrophy (GA))]. There was a significant correlation between AMD stages and OA grading score. There were significant differences between OA patient with AMD and those without AMD regarding age, disease duration, disease severity, family history of OA, daily mild exercise and calcium, and vitamin D intake. Multivariable analysis revealed that older age, more severe OA, low exercise and less calcium and vitamin D intake were considered independent risk factors for AMD development in primary OA.
Primary OA patients are more liable to AMD due to common risk factors and related pathogenesis. Ophthalmological follow up of those patients is recommended.
原发性骨关节炎（OA）和年龄相关性黄斑变性（AMD）都会导致老年人残疾。本研究旨在检测埃及老年人群样本中原发性骨关节炎与年龄相关性黄斑变性之间的关系。
这项横断面研究纳入了222例原发性OA患者。进行了病史采集、肌肉骨骼检查、体重指数（BMI）计算、眼科检查、双髋和双膝前后位及负重位的X线片以及双手后前位X线片、OA放射学严重程度的Kellgren和Lawrence分级评分、光学相干断层扫描（OCT）以及用于评估黄斑的眼底荧光血管造影（FFA）。AMD分为早期、中期和晚期。使用SPSS 25.0版对收集的数据进行分析。
46例OA患者患有AMD[19例为早期，15例为中期，12例为晚期（7例新生血管（NV）和5例地图状萎缩（GA））]。AMD分期与OA分级评分之间存在显著相关性。患有AMD的OA患者与未患有AMD的OA患者在年龄、病程、疾病严重程度、OA家族史、日常轻度运动以及钙和维生素D摄入量方面存在显著差异。多变量分析显示，年龄较大、OA更严重、运动少以及钙和维生素D摄入量少被认为是原发性OA中发生AMD的独立危险因素。
由于共同的危险因素和相关发病机制，原发性OA患者更容易患AMD。建议对这些患者进行眼科随访。
