Zhou Xinyi, Jin Nan, Wang Fei, Chen Baoan
Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing, 210009 Jiangsu People's Republic of China.
Cancer Cell Int. 2020 Apr 7;20:114. doi: 10.1186/s12935-020-01193-z. eCollection 2020.
It is well acknowledged that allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for numerous malignant blood diseases, which has also been applied to autoimmune diseases for more than a decade. Whereas graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) as a common serious complication, seriously affecting the efficacy of transplantation. Mesenchymal stem cells (MSCs) derived from a wealth of sources can easily isolate and expand with low immunogenicity. MSCs also have paracrine and immune regulatory functions, leading to a broad application prospect in treatment and tissue engineering. This review focuses on immunoregulatory function of MSCs, factors affecting mesenchymal stem cells to exert immunosuppressive effects, clinical application of MSCs in GVHD and researches on MSC-derived extracellular vesicles (EVs). The latest research progress on MSC in related fields is reviewed as well. The relevant literature from PubMed databases is reviewed in this article.
众所周知，异基因造血干细胞移植（allo-HSCT）是治疗多种恶性血液病的有效方法，并且在自身免疫性疾病治疗中也已应用了十多年。然而，移植物抗宿主病（GVHD）是异基因造血干细胞移植（allo-HSCT）后发生的常见严重并发症，严重影响移植疗效。来源于丰富来源的间充质干细胞（MSCs）易于分离和扩增，免疫原性低。MSCs还具有旁分泌和免疫调节功能，在治疗和组织工程方面具有广阔的应用前景。本综述聚焦于MSCs的免疫调节功能、影响间充质干细胞发挥免疫抑制作用的因素、MSCs在GVHD中的临床应用以及对MSCs来源的细胞外囊泡（EVs）的研究。同时也综述了相关领域中MSCs的最新研究进展。本文回顾了来自PubMed数据库的相关文献。
