Piloto Valdés L J, Valdés Sánchez A F, Gómez Echevarría A H
Allergology Service, Hnos. Ameijeiras Clinical Surgical Hospital, Havana, Cuba.
Allergol Immunopathol (Madr). 1988 Jul-Aug;16(4):267-71.
Thirty-two adult patients with atopic dermatitis were studied at the Allergology Service of the "Hnos. Ameijeiras" Clinical Surgical Hospital. The diagnosis was established following the criteria of Hanifin and Lobitz. A detailed medical history was written for the patients; the study of some immunological parameters, such as the serum immunoglobulin quantification, delayed skin tests with a battery of antigens, and the spontaneous rosette-test, was also carried out. Almost all the patients showed serum IgE values above 150 UI, by means of the ELISA test modified by C.E.N.I.C. The mean values of the spontaneous rosette-test were low; this was more noticeable during the exacerbation period of the lesions. Candida sp, Mantoux and Streptokinase-Streptodornase antigens showed negative results in a high proportion of patients with atopic dermatitis, in relation with the control group. In atopic dermatitis, there are humoral disorders of immunity; this was demonstrated in our group by increased values of IgE and cellular disorders due to skin anergy, and to a low percentage of rosette forming cells; this does not allow to state that these phenomena have an active participation in the etiopathogenesis of this entity.
在“阿梅耶拉斯兄弟”临床外科医院过敏科对32例成年特应性皮炎患者进行了研究。诊断依据Hanifin和Lobitz的标准确定。为患者撰写了详细的病史；还对一些免疫学参数进行了研究，如血清免疫球蛋白定量、一系列抗原的迟发性皮肤试验以及自发玫瑰花结试验。通过由委内瑞拉国家科学研究所（C.E.N.I.C.）改良的ELISA试验，几乎所有患者的血清IgE值均高于150 UI。自发玫瑰花结试验的平均值较低；在皮损加重期这种情况更为明显。与对照组相比，白色念珠菌、结核菌素和链激酶 - 链道酶抗原在高比例的特应性皮炎患者中呈阴性结果。在特应性皮炎中，存在体液免疫紊乱；在我们的研究组中表现为IgE值升高以及由于皮肤无反应性和低比例的玫瑰花结形成细胞导致的细胞紊乱；但这并不足以说明这些现象在该疾病的病因发病机制中具有积极作用。
