Pauly C R, Artis W M, Jones H E
Arch Dermatol. 1978 Mar;114(3):391-3.
A substantial elevation in the level of serum IgE (7,000 to 19,000 ng/ml) was noted in a man with atopic dermatitis and chronic molluscum contagiosum. Cell-mediated immunity (CMI) was depressed in vivo (cutaneous anergy), whereas in vitro tests showed normal numbers of "T" rosette-forming lymphocytes, a normal phytohemagglutinin-P-elicited lymphocyte transformation response, and lymphocyte transformation reactivity to the antigens streptokinase-streptodornase and purified protein derivative. Accumulated evidence suggests that patients with atopic dermatitis may have, associated with an elevated serum IgE level, a functional defect(s) in CMI that is greater in vivo than in vitro. This functional defect may impair host defense and account for the chronic molluscum contagiosum infection present in this patient.
在一名患有特应性皮炎和慢性传染性软疣的男性患者中，发现其血清IgE水平显著升高（7000至19000 ng/ml）。该患者体内的细胞介导免疫（CMI）功能低下（皮肤无反应性），而体外试验显示“T”花环形成淋巴细胞数量正常，植物血凝素-P诱导的淋巴细胞转化反应正常，对链激酶-链道酶和纯化蛋白衍生物抗原的淋巴细胞转化反应性也正常。越来越多的证据表明，特应性皮炎患者除血清IgE水平升高外，可能还存在CMI功能缺陷，且这种缺陷在体内比在体外更明显。这种功能缺陷可能会损害宿主防御功能，导致该患者出现慢性传染性软疣感染。
