Moreno M V, Fernández M, Oehling A
University of Navarra, Faculty of Medicine, Department of Allergology, Pamplona, Spain.
Allergol Immunopathol (Madr). 1988 Sep-Oct;16(5):369-72.
The Melkersson-Rosenthal Syndrome consists of recurrent edema of the lips, intermittent facial edema and a furrowed tongue. This is the classic triad which defines the syndrome, although it is accepted that the presence of two manifestations is sufficient to make the diagnosis. Distribution is universal although the majority of the cases are described in the European literature. The case of a 37 year-old female is presented. She came to consult for persistent edema of the upper lip, of a three-year duration, which started abruptly without any clear etiologic correlation with acute episodes that disappear spontaneously or with corticoid treatment. Associated symptoms included migraine headaches which started years earlier. The complimentary examinations were normal except for a mild elevation of the sedimentary rate, and the biopsy was compatible with granulomatous cheilitis. In conclusion, MRS has to be considered as a diagnostic possibility in a patient who consulted for recurrent edema associated with other dermatologic and neurologic manifestations, although not necessarily having the complete triad.
梅尔克森 - 罗森塔尔综合征包括唇部反复水肿、间歇性面部水肿和皱襞舌。这是定义该综合征的经典三联征，不过公认存在两种表现就足以做出诊断。虽然大多数病例在欧洲文献中有描述，但该综合征在全球均有分布。本文介绍了一名37岁女性的病例。她因上唇持续性水肿前来就诊，病程长达三年，起病突然，与急性发作无明确病因关联，急性发作可自行消失或经皮质类固醇治疗后消失。相关症状包括数年前开始出现的偏头痛。除血沉轻度升高外，其他辅助检查均正常，活检结果符合肉芽肿性唇炎。总之，对于因反复水肿并伴有其他皮肤和神经表现前来就诊的患者，即使不一定具备完整的三联征，也必须考虑梅尔克森 - 罗森塔尔综合征的诊断可能性。
