Genos Glycoscience Research Laboratory, Zagreb, Croatia.
Genos Glycoscience Research Laboratory, Zagreb, Croatia; University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia.
Cell Immunol. 2018 Nov;333:65-79. doi: 10.1016/j.cellimm.2018.07.009. Epub 2018 Jul 23.
The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows a significant degree of variation within populations. IgG glycome composition is influenced both by genes and by environment, making it an excellent biomarker of a person's general health state, i.e. biological age. IgG glycosylation appears to be highly regulated, both during homeostasis and in cases of its disturbance. Changes in IgG glycosylation patterns have been observed in aging and in various diseases. Differential IgG glycosylation is known to modulate IgG effector functions and is involved in disease development and progression, representing both a predisposition and a functional mechanism involved in disease pathology. This makes IgG glycosylation analysis a promising add-on to improve existing disease biomarkers.
免疫球蛋白 G（IgG）糖基化组以其异质性而闻名，在人群中表现出显著的变异性。IgG 糖基化组的组成既受基因影响，也受环境影响，因此是一个人整体健康状况（即生物年龄）的极佳生物标志物。IgG 糖基化在体内平衡和紊乱时都受到高度调控。在衰老和各种疾病中观察到 IgG 糖基化模式的变化。已知差异 IgG 糖基化可调节 IgG 效应功能，并参与疾病的发展和进展，既代表疾病病理学中的易感性，也代表功能机制。这使得 IgG 糖基化分析成为一种很有前途的附加手段，可以改善现有的疾病生物标志物。
