Zhang Yu-Shi, Cong Wei-Hong, Zhang Jing-Jing, Guo Fei-Fei, Li Hong-Mei
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
Zhongguo Zhong Yao Za Zhi. 2020 Mar;45(6):1263-1271. doi: 10.19540/j.cnki.cjcmm.20200219.501.
The outbreak caused by 2019 novel coronavirus(2019-nCoV) is still spreading, posing a great threat to the safety and health of general population. However, there have not been any effective drugs for treatment, with symptomatic treatment and prevention prevailing. The treatment plans of severe acute respiratory syndrome(SARS) and Middle East respiratory syndrome(MERS) are often used for reference in clinic. The advantages of traditional Chinese medicine(TCM) in treating SARS and MERS are that it can intervene and block the progression of disease in early stage, significantly reduce symptoms, shorten the treatment duration of patients, reduce complications and side effects caused by hormone therapy. The coronavirus disease 2019(COVID-19) belongs to the category of TCM epidemic diseases. Chinese patent medicines and prescriptions in medical observation and clinical treatment were recommended in the "pneumonia diagnosis and treatment plan for new coronavirus infection"(trial version fifth) of the National Health Commission of the People's Republic of China. Qingfei Paidu Decotion was recommended for the treatment of COVID-19 by the National Health Commission of the People's Republic of China and National Administration of Traditional Chinese Medicine. TCM shows good clinical efficacy and great potential in the treatment of COVID-19. Previous studies of TCM have shown broad-spectrum antiviral activity, providing a variety of sources for the discovery of new antiviral drugs. In this paper, we reviewed traditional Chinese medicines and its active ingredients in the hope of bringing novel inspirations to the drug screening and clinical treatment for COVID-19.
2019新型冠状病毒（2019-nCoV）引发的疫情仍在蔓延，对普通民众的安全与健康构成巨大威胁。然而，目前尚无有效的治疗药物，主要采取对症治疗和预防措施。临床中常参考严重急性呼吸综合征（SARS）和中东呼吸综合征（MERS）的治疗方案。中医在治疗SARS和MERS方面的优势在于，它能够在疾病早期进行干预并阻断病情发展，显著减轻症状，缩短患者的治疗时间，减少激素治疗引起的并发症和副作用。新型冠状病毒肺炎（COVID-199）属于中医疫病范畴。中华人民共和国国家卫生健康委员会《新型冠状病毒感染的肺炎诊疗方案（试行第五版）》推荐了医学观察期及临床治疗中的中成药和方剂。清肺排毒汤被中华人民共和国国家卫生健康委员会和国家中医药管理局推荐用于治疗COVID-19。中医在治疗COVID-19方面显示出良好的临床疗效和巨大潜力。以往对中药的研究已显示出广谱抗病毒活性，为发现新型抗病毒药物提供了多种来源。在本文中，我们对中药及其活性成分进行了综述，希望能为COVID-19的药物筛选和临床治疗带来新的启发。
