Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France.
Nutritional and Environmental Section, Thailand Initiatives for Functional Medicine, Bangkok, Thailand.
Curr Med Chem. 2024;31(21):3118-3131. doi: 10.2174/0929867330666230331084126.
The coronavirus disease 2019 (COVID-19) pandemic still has tremendous impacts on the global socio-economy and quality of living. The traditional Chinese Medicines (TCM) approach showed encouraging results during previous outbreaks of Severe Acute Respiratory Syndrome-related Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). With limited treatment availability, TCM herbs and formulations could be useful to reduce COVID-19 symptoms and potential sources for discovering novel therapeutic targets. We reviewed 12 TCM herbs and formulations recommended for COVID-19 management by the National Health Commission and as National Administration of Traditional Chinese Medicine of the People's Republic of China. This article explored the Chinese national authorities' guidelines from 2003 to 2020, the scientific data in public databases for the recommended TCM remedies, and their potential mechanistic actions in COVID-19 management. Several TCM herbs and formulations could potentially benefit COVID-19 management. The recommended TCM oral preparations list includes , and ; the recommended injection preparations comprise Xiyanping , and . TCM remedies are viable options for symptom alleviation and management of COVID-19. The current SARS-CoV-2 pandemic presents an opportunity to find novel therapeutic targets from TCM-active ingredients. Despite the recommendations in Chinese National guidelines, these remedies warrant further assessments in well-designed clinical trials to ascertain their efficacy in the treatment of COVID-19.
2019 年冠状病毒病(COVID-19)大流行仍对全球社会经济和生活质量产生巨大影响。传统中药(TCM)在以前的严重急性呼吸系统综合征相关冠状病毒(SARS-CoV)和中东呼吸系统综合征冠状病毒(MERS-CoV)爆发期间显示出令人鼓舞的结果。由于治疗方法有限,TCM 草药和配方可能有助于减轻 COVID-19 症状,并为发现新的治疗靶点提供潜在来源。我们回顾了国家卫生健康委员会和中华人民共和国国家中医药管理局推荐用于 COVID-19 管理的 12 种 TCM 草药和配方。本文探讨了中国国家当局 2003 年至 2020 年的指南、公共数据库中推荐的 TCM 补救措施的科学数据,以及它们在 COVID-19 管理中的潜在机制作用。几种 TCM 草药和配方可能对 COVID-19 管理有益。推荐的 TCM 口服制剂包括连花清瘟胶囊、金花清感颗粒、疏风解毒胶囊;推荐的注射制剂包括喜炎平注射液、血必净注射液。TCM 补救措施是缓解 COVID-19 症状和管理的可行选择。目前的 SARS-CoV-2 大流行为从 TCM 活性成分中寻找新的治疗靶点提供了机会。尽管中国国家指南有这些建议,但这些补救措施仍需要在精心设计的临床试验中进行进一步评估,以确定它们在 COVID-19 治疗中的疗效。
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