Haney S M, Butler F O, Heerema N A
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46223.
Am J Med Genet. 1988 Nov;31(3):663-7. doi: 10.1002/ajmg.1320310322.
We report on the spontaneous expression of fra(10)(q25) in bone marrow from a patient with agranulocytosis. Expression of this fragile site in both bone marrow and leukocytes was enhanced by bromodeoxyuridine (BrdU), while folic-acid-deficient medium enhanced the expression of fra(10)(q25) only in leukocytes. Variability in the expression of fra(10)(q25) in bone marrow and leukocyte cultures over an 18-month period was also found.
