Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, China; Department of Traditional Chinese Medicine, The First Affiliated Hospital of Shandong First Medical University, Ji'nan, China.
College of Bioengineering, Qilu University of Technology (Shandong Academy of Sciences), Ji'nan, China.
Microb Pathog. 2020 Jul;144:104196. doi: 10.1016/j.micpath.2020.104196. Epub 2020 Apr 10.
Urinary tract infection (UTI) is caused by the invasion of the pathogen in the urinary system that can manifest as symptomatic or asymptomatic bacteriuria. This study was conducted to investigate antibiotic resistance patterns, and the correlation between biofilm formations with virulence factors in uropathogenic E. coli isolates retrieved from UTI. We searched Scopus and Google Scholar, PubMed, Web of sciences for studies published in the English language between 1st 2005 to 31st December 2019. The Mesh terms and text words included "biofilms", OR "biofilm formation", AND "antibiotic resistance", OR "drug-resistance", OR "antimicrobial drug resistance", AND "urinary tract infections", OR "UTI", AND "biofilm related-genes", AND "virulence factors" AND "correlation", AND "Uropathogenic Escherichia coli", OR "Uropathogenic E. coli" AND "prevalence" AND "Iran". Data analyzed using Comprehensive Meta-Analysis (CMA) software. The random-effects model was used to calculate the pooled prevalence with 95% confidence interval (CI). The combined rates of biofilm formation in Uropathogenic E. coli (UPEC) isolates were achieved as 84.6% (95% CI: 72.7-91.9). Also, 24.8%, 26.1% and 44.6% of UPEC isolates were able to create strong, moderate and weak biofilm, respectively. The highest pooled antibiotic resistance was against Ampicillin followed by Tetracycline with resistance rates of 74.6% and 64.9%, respectively. Accordingly, some studies reported that biofilm production was significantly associated with antibiotic resistance and virulence genes (p < 0.05). This study showed a high tendency among UPEC isolates to form biofilm (more than 84%), also, most studies included in the present review reported a significant correlation between biofilm formation with antibiotic resistance and virulence factors.
尿路感染（UTI）是由病原体侵入泌尿系统引起的，可表现为有症状或无症状的菌尿。本研究旨在调查尿路感染中产脲原体大肠杆菌分离株的抗生素耐药模式以及生物膜形成与毒力因子之间的相关性。我们在 Scopus 和 Google Scholar、PubMed、Web of Sciences 中检索了 2005 年 1 月 1 日至 2019 年 12 月 31 日期间以英文发表的研究。Mesh 术语和文本词包括“生物膜”、“生物膜形成”和“抗生素耐药性”、“耐药性”、“抗微生物药物耐药性”和“尿路感染”、“UTI”、“生物膜相关基因”、“毒力因子”和“相关性”、“尿路致病性大肠杆菌”、“尿路致病性大肠杆菌”和“流行率”和“伊朗”。使用 Comprehensive Meta-Analysis（CMA）软件分析数据。使用随机效应模型计算合并的 95%置信区间（CI）的汇总患病率。尿路致病性大肠杆菌（UPEC）分离株生物膜形成的合并率为 84.6%（95%CI：72.7-91.9）。此外，24.8%、26.1%和 44.6%的 UPEC 分离株能够分别形成强、中、弱生物膜。UPEC 分离株对抗生素氨苄西林的耐药率最高，其次是四环素，耐药率分别为 74.6%和 64.9%。相应地，一些研究报道生物膜的产生与抗生素耐药性和毒力基因显著相关（p<0.05）。本研究表明 UPEC 分离株形成生物膜的趋势较高（超过 84%），此外，本综述中包含的大多数研究报告生物膜形成与抗生素耐药性和毒力因子之间存在显著相关性。
