Plant Stress Physiology Lab, Department of Botanical and Environment Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
Department of Bio-organic and Biological Chemistry, Kharkiv National Medical University, Kharkiv 61000, Ukraine.
Biomolecules. 2020 Apr 9;10(4):572. doi: 10.3390/biom10040572.
Steroids are a pivotal class of hormones with a key role in growth modulation and signal transduction in multicellular organisms. Synthetic steroids are widely used to cure large array of viral, fungal, bacterial, and cancerous infections. Brassinosteroids (BRs) are a natural collection of phytosterols, which have structural similarity with animal steroids. BRs are dispersed universally throughout the plant kingdom. These plant steroids are well known to modulate a plethora of physiological responses in plants leading to improvement in quality as well as yield of food crops. Moreover, they have been found to play imperative role in stress-fortification against various stresses in plants. Over a decade, BRs have conquered worldwide interest due to their diverse biological activities in animal systems. Recent studies have indicated anticancerous, antiangiogenic, antiviral, antigenotoxic, antifungal, and antibacterial bioactivities of BRs in the animal test systems. BRs inhibit replication of viruses and induce cytotoxic effects on cancerous cell lines. Keeping in view the biological activities of BRs, this review is an attempt to update the information about prospects of BRs in biomedical and clinical application.
甾体激素是一类重要的激素，在多细胞生物的生长调节和信号转导中起着关键作用。合成甾体激素被广泛用于治疗多种病毒、真菌、细菌和癌症感染。油菜素甾醇（BRs）是植物甾醇的天然集合体，与动物甾体激素具有结构相似性。BRs 在植物界中广泛分布。这些植物甾体激素在植物中调节多种生理反应，从而提高粮食作物的质量和产量。此外，人们发现它们在植物对各种胁迫的强化应激中起着重要作用。BRs 在动物系统中的多种生物学活性在过去十年中引起了全球关注。最近的研究表明，BRs 在动物测试系统中具有抗癌、抗血管生成、抗病毒、抗原毒性、抗真菌和抗菌的生物活性。BRs 抑制病毒复制，并对癌细胞系产生细胞毒性作用。鉴于 BRs 的生物学活性，本综述试图更新关于 BRs 在生物医学和临床应用方面的前景信息。
