Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, La Sapienza University of Rome, 00161 Rome, Italy.
Int J Environ Res Public Health. 2020 Apr 9;17(7):2580. doi: 10.3390/ijerph17072580.
Mancozeb is a widely used fungicide approved for use in agriculture in many countries with long persistence in the environment and consequent bioaccumulation in tissues and biological fluids. Despite the large amount of studies published in recent years, the relationship between mancozeb exposure and female reproductive health is not fully elucidated. In order to summarize current evidence on mancozeb exposure and female reproductive disease, we performed a systematic review of literature. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to make this review. An adapted version of the National Toxicology Program's Office of Health and Assessment and Translation (OHAT) framework was used to evaluate the risk of bias. Electronic search on two databases (PubMed and Scopus) was used to find experimental studies (in vitro and in vivo) on mancozeb exposure. The database search identified 250 scientific articles, 20 of which met our inclusion criteria. Selected data were then reviewed and summarized in tables. Overall, mancozeb represents a hazard for female reproductive health, with different mechanisms of action. Undoubtedly more experimental and epidemiological studies are required to definitively validate mancozeb as reproductive toxicant.
代森锰锌是一种广泛使用的杀菌剂，在许多国家的农业中得到批准使用，它在环境中有很长的持久性，因此会在组织和生物液中生物累积。尽管近年来发表了大量的研究，但代森锰锌暴露与女性生殖健康之间的关系尚未完全阐明。为了总结代森锰锌暴露与女性生殖疾病的现有证据，我们对文献进行了系统评价。本综述采用了系统评价和荟萃分析的首选报告项目（PRISMA）指南。采用了国家毒理学计划办公室健康评估和转化（OHAT）框架的改编版本来评估偏倚风险。在两个数据库（PubMed 和 Scopus）上进行了电子搜索，以查找代森锰锌暴露的实验研究（体外和体内）。数据库搜索确定了 250 篇科学文章，其中 20 篇符合我们的纳入标准。然后对选定的数据进行了审查和总结。总的来说，代森锰锌对女性生殖健康构成危害，其作用机制不同。毫无疑问，需要更多的实验和流行病学研究来最终确定代森锰锌是否具有生殖毒性。
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