Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 1215 21st Avenue South, Suite 5037, Nashville, TN 37232, USA.
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 300A, Nashville, TN 37203, USA.
Cardiol Clin. 2020 May;38(2):269-281. doi: 10.1016/j.ccl.2020.01.002. Epub 2020 Feb 28.
Pulmonary arterial hypertension is a highly morbid disease with limited treatment options that improve survival and currently the only curative treatment is transplantation. There is a small body of literature comparing the efficacy of lung and heart-lung transplantation in this population. The bulk of evidence suggests that most patients with severe right ventricular failure undergoing transplant will have recovery of right ventricular function after lung transplantation. Existing data suggest that, in the absence of complex congenital heart disease or significant left ventricular dysfunction, double-lung transplant is the surgical procedure of choice.
肺动脉高压是一种高度病态的疾病,治疗选择有限,目前唯一的根治方法是移植。有少量文献比较了肺移植和心肺移植在这一人群中的疗效。大多数证据表明,大多数接受移植的严重右心衰竭患者在肺移植后右心功能将恢复。现有数据表明,在没有复杂先天性心脏病或明显左心功能障碍的情况下,双肺移植是首选的手术方法。