右心-肺循环单元：病理生理学。
The Right Heart-Pulmonary Circulation Unit: Physiopathology.
机构信息
Department of Cardiology, Erasme University Hospital, Brussels, Belgium.
Division of Translational and Regenerative Medicine, University of Arizona, Tucson, AZ, USA.
出版信息
Heart Fail Clin. 2018 Jul;14(3):237-245. doi: 10.1016/j.hfc.2018.02.001.
The most common cause of right heart failure is increased afterload caused by pulmonary hypertension. Right ventricular function adaptation to increased afterload is basically systolic, with secondary increase in dimensions and systemic congestion. Increased right ventricular dimensions and decreased ejection fraction are associated with a decreased survival in severe pulmonary hypertension. Targeted therapies titrated to reverse the right ventricular remodeling dimensions improve survival in severe pulmonary hypertension.
右心衰竭最常见的原因是肺动脉高压引起的后负荷增加。右心室对增加的后负荷的功能适应基本上是收缩期的，伴随着尺寸和全身充血的继发性增加。右心室尺寸增加和射血分数降低与严重肺动脉高压患者的生存率降低有关。针对逆转右心室重构尺寸的靶向治疗可改善严重肺动脉高压患者的生存率。
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