The value of lncRNA and as a prognostic factor for survival of lung adenocarcinoma.

It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The is a long coding RNA (also named ) located in the vicinity of the protein-coding gene at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA in lung adenocarcinomas. expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA hybridization (RNA-FISH) corroborated independently the down-regulation of . Interestingly, the expression of correlated positively (p<0.001) with the expression of its protein-coding neighbor gene . Additionally, expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with expression (p=0.01). In conclusion, our data support that and expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers.