Linseman M A
Biobehavioral Research Department, Addiction Research Foundation, Toronto, Canada.
Alcohol. 1988 Jul-Aug;5(4):301-3. doi: 10.1016/0741-8329(88)90069-9.
A number of recent studies have shown that free-feeding rats will consume pharmacologically significant amounts of alcohol when given access to alcohol for short periods of time daily. The present experiment was designed to examine the role of taste in inducing alcohol consumption in this type of periodic availability paradigm, by comparing amounts drunk thereby to amounts of another bitter solution, sucrose octa acetate (SOA), presented on a similar schedule. In contrast to alcohol, which was consistently preferred to water, at a concentration as high as 12% (w/v), preference for SOA diminished across days, indicating that the bitter taste alone was insufficient to increase consumption of this solution. The results also suggest the animals may be drinking in response to external conditioning stimuli, an effect which has previously been demonstrated in regard to feeding.
最近的一些研究表明，自由进食的大鼠在每天短时间接触酒精时，会摄入具有药理学意义的大量酒精。本实验旨在通过比较大鼠在这种周期性可得范式下饮用酒精的量与以类似时间表呈现的另一种苦味溶液——蔗糖八乙酸酯（SOA）的摄入量，来研究味觉在诱导酒精消费中的作用。与始终比水更受青睐的酒精不同，在浓度高达12%（w/v）时，大鼠对SOA的偏好随时间推移而降低，这表明仅苦味不足以增加该溶液的摄入量。结果还表明，动物可能是对外部条件刺激做出反应而饮水，这种效应先前在进食方面已得到证实。
