Hawley R J, Schulman E, Major L F, Poplack J, Catravas G N
Department of Neurology, Georgetown University, Washington, DC.
Alcohol. 1988 Jul-Aug;5(4):321-3. doi: 10.1016/0741-8329(88)90073-0.
Cerebrospinal fluid (CSF) histidine concentration was significantly elevated in seven patients early in the alcohol withdrawal syndrome (206.3 +/- 74.4 (SEM) nanomols/ml CSF). When these same patients were restudied an average of six days later when alcohol withdrawal was clinically resolved, their mean CSF histidine concentration continued to be significantly elevated (164.7 +/- 24.7) when compared to normal (12.0 +/- 0.5 nanomols/ml CSF). Other amino acids (aspartic acid, serine, alanine, methionine, leucine, tyrosine, phenylalanine, lysine and arginine) showed no definite changes from normal, and no change during the course of alcohol withdrawal. Possible reasons for these high concentrations and the extreme variability (especially early in alcohol withdrawal) are discussed.
在酒精戒断综合征早期，7名患者的脑脊液（CSF）组氨酸浓度显著升高（206.3±74.4（标准误）纳摩尔/毫升脑脊液）。当这些患者在平均六天后酒精戒断在临床上得到缓解时再次接受研究，与正常情况（12.0±0.5纳摩尔/毫升脑脊液）相比，他们的脑脊液组氨酸平均浓度仍显著升高（164.7±24.7）。其他氨基酸（天冬氨酸、丝氨酸、丙氨酸、蛋氨酸、亮氨酸、酪氨酸、苯丙氨酸、赖氨酸和精氨酸）与正常情况相比没有明显变化，在酒精戒断过程中也没有变化。文中讨论了这些高浓度以及极端变异性（尤其是在酒精戒断早期）的可能原因。
