Hawley R J, Major L F, Schulman E A, Lake C R
Arch Neurol. 1981 May;38(5):289-92. doi: 10.1001/archneur.1981.00510050055008.
Cerebrospinal fluid norepinephrine (NE) levels were determined by radioenzymatic assay in 21 patients with a variety of neurological diseases and 49 patients in acute alcohol withdrawal. A second determination was made in 19 patients who had recovered from the alcohol withdrawal syndrome. Cerebrospinal fluid NE concentration was higher in the patients during alcohol withdrawal (192.3 plus or minus 22.3 pg/mL) and decreased during recovery to 137.8 plus or minus 15.9 pg/mL. The CSF NE level was higher in both groups than in patients with other neurological disorders. This may help explain the adrenergic signs observed during alcohol withdrawal.
采用放射酶分析法测定了21例患有各种神经系统疾病的患者以及49例急性酒精戒断患者的脑脊液去甲肾上腺素（NE）水平。对19例已从酒精戒断综合征中康复的患者进行了第二次测定。酒精戒断期间患者的脑脊液NE浓度较高（192.3±22.3 pg/mL），康复期间降至137.8±15.9 pg/mL。两组患者的脑脊液NE水平均高于其他神经系统疾病患者。这可能有助于解释酒精戒断期间观察到的肾上腺素能体征。
