瑞士一项机构回顾性研究系列中123例同时性或异时性双侧乳腺癌患者的临床病理特征、治疗及预后
Clinicopathological Characteristics, Treatment and Outcome of 123 Patients with Synchronous or Metachronous Bilateral Breast Cancer in a Swiss Institutional Retrospective Series.
作者信息
Huber Alexandre, Seidler Stéphanie J, Huber Daniela E
机构信息
Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Gynecology Department, Hôpital du Valais, Sierre, Switzerland.
出版信息
Eur J Breast Health. 2020 Apr 1;16(2):129-136. doi: 10.5152/ejbh.2020.5297. eCollection 2020 Apr.
OBJECTIVE
To evaluate the prognosis, the patient and tumor characteristics, and the treatment of bilateral breast cancer (BBC) and to compare synchronous (sBBC) and metachronous BBC (mBBC).
MATERIALS AND METHODS
For this retrospective study, data from 123 consecutive BBC patients (56 sBBC and 67 mBBC) that were presented at the Sion Hospital tumor board between 2007 and 2018 were collected retrospectively.
RESULTS
Mean follow-up was 85 months. 2 tumors in both groups were more often diagnosed radiologically. Mean time interval between mBBC was 115 months. A shorter interval was positively correlated with a negative hormonal receptor (HR) status and higher grade for the 2 tumor. There was no difference in overall survival (OS) and relapse-free survival (RFS) between sBBC and mBBC. OS was longer if both tumors were hormonal receptor (HR) positive. mBBC exhibited a higher local recurrence rate than sBBC (p=0.03).
CONCLUSION
sBBC and mBBC patients did not show any difference in OS or RFS, although mBBC patients were more prone to local relapses.
目的
评估双侧乳腺癌（BBC）的预后、患者及肿瘤特征以及治疗情况，并比较同步性双侧乳腺癌（sBBC）和异时性双侧乳腺癌（mBBC）。
材料与方法
在这项回顾性研究中，回顾性收集了2007年至2018年间在锡永医院肿瘤委员会就诊的123例连续BBC患者（56例sBBC和67例mBBC）的数据。
结果
平均随访时间为85个月。两组中的2个肿瘤更多是通过影像学诊断的。mBBC之间的平均时间间隔为115个月。较短的间隔与2个肿瘤的激素受体（HR）阴性状态和更高分级呈正相关。sBBC和mBBC之间的总生存期（OS）和无复发生存期（RFS）没有差异。如果两个肿瘤均为激素受体（HR）阳性，则OS更长。mBBC的局部复发率高于sBBC（p = 0.03）。
结论
sBBC和mBBC患者在OS或RFS方面没有差异，尽管mBBC患者更容易发生局部复发。
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