Department of Ophthalmology, Military Medical Academy, 21/1 Botkinskaya St., St. Petersburg, Russia, 194044.
UPMC Eye Center, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA, 15213, USA.
Int Ophthalmol. 2020 Aug;40(8):1913-1921. doi: 10.1007/s10792-020-01363-y. Epub 2020 Apr 13.
To analyze the efficacy of navigated focal laser photocoagulation (FLP) of microaneurysms in diabetic macular edema (DME) planned using en face optical coherence tomography (OCT) as against fluorescein angiography (FA).
Twenty-six eyes of 21 DME patients (12 males, 9 females, 69.5 ± 12.3 years) with mean BCVA of 0.52 ± 0.44 LogMAR were included. En face OCT images of deep capillary plexus slab and FA images were used to plan FLP targeting of leaky microaneurysms. The primary outcome measures were central retinal thickness (CRT) and macular volume. The secondary outcome measure was best-corrected visual acuity (BCVA).
The difference in the change of CRT and macular volume between en face OCT and FA-planned FLP after 1 month and at the end of follow-up was not statistically significant (p > 0.05), except for a higher CRT reduction in the en face OCT-planning group (p = 0.007) at the end of mean follow-up of 2.6 ± 0.9 months. There was no difference in BCVA change between the two planning options (p = 0.42).
En face OCT is a non-inferior alternative for FA in the planning of navigated FLP of microaneurysms in DME.
分析使用针对糖尿病性黄斑水肿（DME）的微动脉瘤的面内光相干断层扫描（OCT）规划导航聚焦激光光凝（FLP）与荧光素血管造影（FA）相比的疗效。
纳入 21 例 DME 患者（12 名男性，9 名女性，69.5±12.3 岁）的 26 只眼，平均 BCVA 为 0.52±0.44 LogMAR。使用深层毛细血管丛平板的面内 OCT 图像和 FA 图像来规划针对渗漏微动脉瘤的 FLP。主要观察指标为中心视网膜厚度（CRT）和黄斑体积。次要观察指标为最佳矫正视力（BCVA）。
1 个月和随访结束时，面内 OCT 和 FA 规划 FLP 后 CRT 和黄斑体积变化的差异无统计学意义（p＞0.05），除了平均随访 2.6±0.9 个月结束时面内 OCT 规划组 CRT 降低更明显（p=0.007）。两种规划方案的 BCVA 变化无差异（p=0.42）。
在 DME 微动脉瘤的导航 FLP 规划中，面内 OCT 是 FA 的非劣效替代方案。
