Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.
University Animal Hospital, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Equine Vet J. 2021 Jan;53(1):143-148. doi: 10.1111/evj.13266. Epub 2020 Apr 24.
Light-emitting diodes (LEDs) are commonly used for treating a variety of disorders in horses, including wounds. Despite its claim to shorten healing times, there is a lack of scientific documentation regarding its effects.
To investigate if treatment with pulsating visible red light (λ ≈ 637 nm) and near-infrared (NIR) light (λ ≈ 956 nm) affects wound healing.
Randomised blinded controlled experimental study.
A circular skin wound (Ø = 2 cm) was created on each side of the neck in eight healthy horses. One randomly chosen wound received light treatment and the other served as an untreated control. Treatment duration was 4 minutes and 40 seconds (red light 95 seconds, 2.3 mW/cm ; NIR light 185 seconds, 6.4 mW/cm ) and was performed once daily on day 0-4, 7-11, 14-18 and 21-25. The wounds were photographed and evaluated using digital photoplanimetry on day 0, 1, 2, 3, 4, 7, 14, 21, 28 and 35. The degree of swelling was assessed with diagnostic ultrasound on the same days except the last recording was performed on day 36 instead of 35. Days to total healing was recorded. ANOVA was used for statistical analysis (P < .05).
The wound area (P = .2-.9) and degree of swelling (P = .2-1.0) did not differ between treated and control groups on any day. There was a significant difference (P = .03) in healing time between control (49.0, 95% CI = 35.4-62.6 days) and treated wounds (51.8, 95% CI = 38.7-64.8 days).
The wounds were treated until day 25 and this study does not investigate the effect of a longer treatment period than 25 days.
The results of this study do not indicate any clinically relevant positive effect of pulsating visible red light and NIR light on the healing of experimental skin wounds in horses, compared with no treatment.
发光二极管（LED）常用于治疗马的各种疾病，包括伤口。尽管它声称可以缩短愈合时间，但关于其效果的科学文献却很少。
研究脉冲可见红光（λ≈637nm）和近红外光（NIR）（λ≈956nm）治疗是否会影响伤口愈合。
随机盲法对照实验研究。
在 8 匹健康马的颈部两侧各创建一个圆形皮肤伤口（Ø=2cm）。一个随机选择的伤口接受光疗，另一个作为未治疗的对照。治疗时间为 4 分钟 40 秒（红光 95 秒，2.3mW/cm²；NIR 光 185 秒，6.4mW/cm²），每天一次，在第 0-4、7-11、14-18 和 21-25 天进行。在第 0、1、2、3、4、7、14、21、28 和 35 天，使用数字光测法对伤口进行拍照和评估。除最后一次记录在第 36 天而不是第 35 天外，在相同的日子里使用诊断超声评估肿胀程度。记录完全愈合的天数。使用方差分析进行统计分析（P<.05）。
在任何一天，治疗组和对照组的伤口面积（P=.2-.9）和肿胀程度（P=.2-1.0）均无差异。愈合时间在对照组（49.0，95%置信区间=35.4-62.6 天）和治疗组（51.8，95%置信区间=38.7-64.8 天）之间存在显著差异（P=.03）。
伤口治疗至第 25 天，本研究未调查治疗期超过 25 天对伤口愈合的影响。
与不治疗相比，本研究结果表明，脉冲可见红光和近红外光对马实验性皮肤伤口愈合没有任何临床相关的积极影响。
