Más-Montoya Miriam, Montenegro María F, Espinosa Ferao Arturo, Tárraga Alberto, Rodríguez-López José Neptuno, Curiel David
Department of Organic Chemistry, Faculty of Chemistry, University of Murcia, Campus of Espinardo, Murcia 30100, Spain.
Department of Biochemistry and Molecular Biology A, Faculty of Biology, University of Murcia, Campus of Espinardo, Murcia 30100, Spain.
Org Lett. 2020 May 1;22(9):3356-3360. doi: 10.1021/acs.orglett.0c00782. Epub 2020 Apr 14.
The rational design of a rigid π-extended ligand, suitable for the formation of four-coordinate boron complexes, has led to the synthesis of the fused hexacyclic structure of carbazolo[2,1-]phenanthridine. The photophysical characterization of the novel fluorophore revealed a significant Stokes shift whose intramolecular charge transfer origin has been corroborated by computational calculations. The usefulness of the reported -difluoroboryl complex as fluorescent probe with large Stokes shift has been demonstrated for cancer cells imaging.
一种适用于形成四配位硼配合物的刚性π-扩展配体的合理设计，导致了咔唑并[2,1-]菲啶稠合六环结构的合成。这种新型荧光团的光物理表征显示出显著的斯托克斯位移，其分子内电荷转移起源已通过计算得到证实。所报道的二氟硼基配合物作为具有大斯托克斯位移的荧光探针在癌细胞成像中的实用性已得到证明。
