School of Biomedical Engineering, Anhui Medical University, Hefei 230032, China.
School of Chemical Engineering, Anhui University of Science and Technology, Huainan 232001, China.
Molecules. 2023 Jan 11;28(2):733. doi: 10.3390/molecules28020733.
Nitrogen-containing heterocycles are ubiquitous in natural products and drugs. Various organic small molecules with nitrogen-containing heterocycles, such as nitrogen-containing boron compounds, cyanine, pyridine derivatives, indole derivatives, quinoline derivatives, maleimide derivatives, etc., have unique biological features, which could be applied in various biological fields, including biological imaging. Fluorescence cell imaging is a significant and effective imaging modality in biological imaging. This review focuses on the synthesis and applications in direct fluorescence cell imaging of -heterocyclic organic small molecules in the last five years, to provide useful information and enlightenment for researchers in this field.
含氮杂环化合物在天然产物和药物中普遍存在。各种含氮杂环的有机小分子，如含氮硼化合物、花菁、吡啶衍生物、吲哚衍生物、喹啉衍生物、马来酰亚胺衍生物等，具有独特的生物学特性，可应用于包括生物成像在内的各个生物领域。荧光细胞成像在生物成像中是一种重要且有效的成像方式。本综述重点介绍了过去五年中含氮杂环有机小分子在直接荧光细胞成像中的合成及应用，为该领域的研究人员提供了有价值的信息和启示。
