Reddy B S, Martin C W, Wynder E L
Cancer Res. 1977 Jun;37(6):1697-701.
Patients with chronic ulcerative colitis are at increased risk of developing carcinoma of the colon. It has been shown that the concentration of fecal bile acids and neutral sterols was higher in cancer patients than in the comparable healthy controls. Fecal neutral steroids and bile acids were measured in patients with ulcerative colitis, family controls who were immediate relatives of patients, patients with other digestive diseases, and healthy unrelated controls. The fecal excretion of cholesterol, coprostanol, and cholestane-3beta, 5alpha, 6beta-triol was higher in patients with ulcerative colitis than in other groups. Patients with other diseases, family controls, and unrelated controls excreted comparable levels of neutral sterols. Patients with ulcerative colitis excreted levels of bile acids in their feces comparable to those excreted by other groups. These findings suggest that possible interactions between cholesterol metabolites and colonic epithelial cells may be relevant in colon carcinogenesis.
患有慢性溃疡性结肠炎的患者患结肠癌的风险增加。研究表明，癌症患者粪便中胆汁酸和中性固醇的浓度高于可比的健康对照组。对溃疡性结肠炎患者、患者的直系亲属作为家族对照、患有其他消化系统疾病的患者以及健康的非亲属对照进行了粪便中性类固醇和胆汁酸的测量。溃疡性结肠炎患者粪便中胆固醇、粪甾烷醇和胆甾烷 - 3β, 5α, 6β - 三醇的排泄量高于其他组。患有其他疾病的患者、家族对照和非亲属对照排泄的中性固醇水平相当。溃疡性结肠炎患者粪便中胆汁酸的排泄水平与其他组相当。这些发现表明，胆固醇代谢物与结肠上皮细胞之间可能的相互作用可能与结肠癌的发生有关。
