患有大肠癌或患大肠癌风险增加的患者的粪便胆汁酸浓度。
Faecal bile acid concentration of patients with carcinoma or increased risk of carcinoma in the large bowel.
作者信息
Mudd D G, McKelvey S T, Norwood W, Elmore D T, Roy A D
出版信息
Gut. 1980 Jul;21(7):587-90. doi: 10.1136/gut.21.7.587.
Abstract
Faecal 3-hydroxy bile acids were assayed enzymatically in patients with carcinoma, or at increased risk of developing carcinoma of the large bowel. No rise in bile acid concentration was demonstrated in patients with ulcerative colitis, previously resected adenoma, or resected carcinoma. Patients with carcinoma, before treatment, had faecal bile acid concentrations similar to control values, and surgery did not affect the mean level. These findings cast doubt on the importance of the 3-hydroxy bile acid concentration in the faeces in the pathogenesis of large bowel cancer.
摘要
对患有癌症或患大肠癌风险增加的患者的粪便3-羟基胆汁酸进行了酶法测定。溃疡性结肠炎患者、既往切除腺瘤患者或切除癌患者均未出现胆汁酸浓度升高。癌症患者在治疗前的粪便胆汁酸浓度与对照值相似，手术也未影响平均水平。这些发现使人对粪便中3-羟基胆汁酸浓度在大肠癌发病机制中的重要性产生怀疑。
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