De Lorenzo F, Degl'Innocenti S, Ruocco A, Silengo L, Cortese R
Cancer Res. 1977 Jun;37(6):1915-7.
In a systematic study of the mutagenic effect of chemical compounds used as pesticides, we found that D. D. soil fumigant and Telone are mutagenic. The test was performed using the bacterial tester strains following the procedure developed by Ames. The active principle of D. D. soil fumigant and Telone is a mixture of the cis and trans isomers of 1,3-dichloropropene. Both isomers are mutagenic in Salmonella strains TA 1535 and TA 100. 2,3-Dichloro-1-propene, a minor component (5%) of the commercial preparation Telone, was also found to be mutagenic in strains TA 1535 and TA 100. Mutagenesis of these tester strains is an indication of a base-pair substitution event causing a missense mutation. 1,3-Dichloropropene is widely used in agriculture all over the world. In Italy 2,187,100 kg were produced in 1972. In California over 1,000,000 kg of 1,3-dichloropropene-containing pesticides were used in 1971.
在一项对用作杀虫剂的化合物诱变效应的系统性研究中，我们发现滴滴涕土壤熏蒸剂和威百亩具有诱变作用。该测试是按照艾姆斯开发的程序，使用细菌测试菌株进行的。滴滴涕土壤熏蒸剂和威百亩的活性成分是1,3 - 二氯丙烯的顺式和反式异构体的混合物。两种异构体在沙门氏菌菌株TA 1535和TA 100中都具有诱变作用。2,3 - 二氯 - 1 - 丙烯是商业制剂威百亩的一种次要成分（5%），也被发现在菌株TA 1535和TA 100中具有诱变作用。这些测试菌株的诱变作用表明发生了导致错义突变的碱基对替换事件。1,3 - 二氯丙烯在世界各地的农业中广泛使用。1972年意大利的产量为2,187,100千克。1971年加利福尼亚使用了超过1,000,000千克含1,3 - 二氯丙烯的农药。
