Progenitec, Inc., Arlington, Texas.
Department of Mathematics, University of Texas at Arlington, Arlington, Texas.
Adv Wound Care (New Rochelle). 2020 Jun;9(6):312-324. doi: 10.1089/wound.2019.1064. Epub 2019 Dec 27.
While myriads of studies have suggested that a survey of wound pH environment could indicate wound healing activities, it is not clear whether wound alkalinity can be used as a prognostic indicator of nonhealing wounds. Currently available systems cannot reliably assess the pH environment across wounds, which is the objective of this study. A disposable device, DETEC pH, was developed and characterized on its ability to map wound alkalinity by pressing a freshly recovered wound dressing against its test surface. By comparing the wound's alkalinity and size reduction rates (∼7 days) following pH measurement, we assessed the capability of wound alkalinity to prognosticate subsequent short-term wound size reduction rates. The device had high accuracy and specificity in determining the alkalinity of simulated wound fluids soaked onto wound dressing. The type of wound dressing type had an insignificant effect on its detection sensitivity. Upon testing discarded wound dressings from human patients, the device quickly determined alkaline and acidic wounds. Finally, statistical analyses of wound size reduction rates in wounds with various alkalinities confirmed that wound alkalinity has a strong influence on, at least, short-term wound healing activity. Without directly contacting the patient, this device provides a quick assessment of wound alkalinity to prognosticate immediate and short-term wound healing activities. DETEC pH may serve as a prognosis device for wound care specialists during routine wound assessment to predict wound healing progress. This information can assist the decision-making process in a clinical setting and augur well for chronic wound treatment. DETEC pH can also be used as an aid for home health care nurses or health care providers to screen nonhealing wounds outside clinics.
虽然有大量研究表明，对伤口 pH 值环境的调查可以指示伤口愈合活动，但尚不清楚伤口的碱性是否可以用作非愈合性伤口的预后指标。目前可用的系统无法可靠地评估伤口的 pH 值环境，这是本研究的目的。 开发了一种一次性设备 DETEC pH，并对其通过将新回收的伤口敷料压在其测试表面上来绘制伤口碱性的能力进行了表征。通过比较 pH 值测量后伤口的碱性和尺寸减小率（约 7 天），我们评估了伤口碱性预测随后短期伤口尺寸减小率的能力。 该设备在确定浸泡在伤口敷料上的模拟伤口流体的碱性方面具有很高的准确性和特异性。伤口敷料的类型对其检测灵敏度没有显着影响。在用来自人类患者的废弃伤口敷料进行测试后，该设备能够快速确定碱性和酸性伤口。最后，对具有不同碱性的伤口的伤口尺寸减小率进行统计分析证实，伤口碱性至少对短期伤口愈合活动有很大影响。 无需直接接触患者，该设备可快速评估伤口碱性，以预测即时和短期的伤口愈合活动。 DETEC pH 可以作为伤口护理专家在常规伤口评估中的预后设备，以预测伤口愈合进展。这些信息可以为临床环境中的决策过程提供帮助，并为慢性伤口治疗提供良好的预后。DETEC pH 还可以用作家庭保健护士或保健提供者的辅助工具，以在诊所外筛选非愈合性伤口。
