Castro-e-Silva Júnior O, Ceneviva R, Roselino J E
Departamento de Cirurgia e Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1988;21(3):637-40.
This study was designed to determine portal blood flow and mitochondrial and hepatic function during extrahepatic obstruction. Twenty-two male Wistar rats which had undergone bile duct ligation were compared 7 days later to 20 sham-operated controls. Portal flow and mitochondrial respiratory control ratio were reduced by 50% and 35%, respectively (P less than 0.01), and serum alanine-aminotransferase levels increased significantly (P less than 0.01) in the extrahepatic cholestatic group. These results suggest that cholestasis may cause an imbalance between the energy supply and the high demand of the liver leading to a state of partial ischemia.
本研究旨在测定肝外梗阻期间的门静脉血流以及线粒体和肝功能。将22只接受胆管结扎的雄性Wistar大鼠在7天后与20只假手术对照组进行比较。肝外胆汁淤积组的门静脉血流和线粒体呼吸控制率分别降低了50%和35%（P<0.01），血清丙氨酸转氨酶水平显著升高（P<0.01）。这些结果表明，胆汁淤积可能导致肝脏能量供应与高需求之间的失衡，从而导致局部缺血状态。
