糖基化黄酮醇文库的合成。

Li Zhitao, Ngojeh George, DeWitt Paul, Zheng Zhi, Chen Min, Lainhart Brendan, Li Vincent, Felpo Peter

Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902, United States.

Tetrahedron Lett. 2008 Dec 15;49(51):7243-7245. doi: 10.1016/j.tetlet.2008.10.032. Epub 2008 Oct 11.

Flavonols are an important class of natural products isolated from plants. Some glycosylated flavonols showed very interesting biological activities. A library of flavonols has been made through Algar-Flynn-Oyamada reaction from 2'-hydroxyacetophenones and benzaldehydes. Glycosylation of these flavonols with various glycosyl donors affords a library of glycosylated flavonols. These compounds are potentially useful pharmacologically active compounds and will be studied for biological activities.

黄酮醇是从植物中分离出的一类重要天然产物。一些糖基化黄酮醇表现出非常有趣的生物活性。通过阿尔加-弗林-小山反应，由2'-羟基苯乙酮和苯甲醛制备了一个黄酮醇文库。这些黄酮醇与各种糖基供体进行糖基化反应，得到一个糖基化黄酮醇文库。这些化合物是具有潜在药理活性的化合物，将对其生物活性进行研究。