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采用水提法、乙醇提取法和超临界流体萃取技术制备的山茱萸变种早田山茱萸花芽提取物的抗氧化和抗炎活性。

Antioxidant and anti-inflammatory activities of Thunb. var. Hayata flower bud extracts prepared by water, ethanol and supercritical fluid extraction techniques.

作者信息

Hsu Hsia-Fen, Hsiao Pei-Chi, Kuo Tzu-Chen, Chiang Shu-Tuan, Chen Shin-Lung, Chiou Shu-Jiau, Ling Xue-Hua, Liang Ming-Tsai, Cheng Wei-Yi, Houng Jer-Yiing

机构信息

Department of Nutrition, I-Shou University, Kaohsiung, Taiwan.

Metal Industries Research & Development Centre, Kaohsiung, Taiwan.

出版信息

Ind Crops Prod. 2016 Oct 30;89:543-549. doi: 10.1016/j.indcrop.2016.05.010. Epub 2016 Jun 16.

DOI:10.1016/j.indcrop.2016.05.010
PMID:32288271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7127524/
Abstract

Thunberg () has long been used as an antipyretic, anti-inflammatory and anti-infectious agent in East Asia. The subspecies Thunb. var. Hayata () is a variant that mainly grows in Taiwan. This study examined the antioxidant and anti-inflammatory activities of the extracts from the flower buds of these two species. The extracts were obtained by three extraction methods: water extraction, ethanol extraction, and supercritical-CO fluid extraction (SFE). The antioxidant activities of dry (dLJ) extracts were superior to those of extracts. Water extracts possessed higher activities than that prepared by ethanol or SFE. The total polyphenols content, total flavonoids content, and the amount of chlorogenic acid and luteolin-7--glucoside were all higher in the water extracts compared to the other two. The SFE extracts of these two species all exhibited excellent anti-inflammatory activities. Although the water and ethanol extracts of dLJ extracts had higher anti-inflammatory activity than that of extracts, the SFE extracts prepared from fresh flower buds (fLJv) exhibited the highest activity among all extracts. The SFE effectively isolates the bioactive components of and can obtain the extracts with high anti-inflammatory activity.

摘要

在东亚地区，Thunberg（）长期以来一直被用作解热、抗炎和抗感染药物。亚种Thunb. var. Hayata（）是一种主要生长在台湾的变种。本研究考察了这两个物种花芽提取物的抗氧化和抗炎活性。提取物通过三种提取方法获得：水提取、乙醇提取和超临界CO₂流体萃取（SFE）。干燥的（dLJ）提取物的抗氧化活性优于提取物。水提取物的活性高于乙醇提取物或SFE提取物。与其他两种提取物相比，水提取物中的总多酚含量、总黄酮含量以及绿原酸和木犀草素 - 7 - O - 葡萄糖苷的含量均更高。这两个物种的SFE提取物均表现出优异的抗炎活性。虽然dLJ提取物的水提取物和乙醇提取物的抗炎活性高于提取物，但从新鲜花芽（fLJv）制备的SFE提取物在所有提取物中表现出最高活性。SFE能有效分离出的生物活性成分，并可获得具有高抗炎活性的提取物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/3e8be1a78ff9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/5c3fdb237df2/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/fd321df2aa0d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/cf4d66eb8e8d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/bf6062ba2635/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/baef116d93a8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/3e8be1a78ff9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/5c3fdb237df2/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/fd321df2aa0d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/cf4d66eb8e8d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/bf6062ba2635/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/baef116d93a8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bb5/7127524/3e8be1a78ff9/gr5.jpg

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