Castel Guillaume, Tordo Noël
Unité postulante des stratégies antivirales - CNRS URA-3015, Institut Pasteur, 25, rue du Docteur-Roux, 75724 Paris cedex 15.
Rev Francoph Lab. 2009 Dec;2009(417):91-100. doi: 10.1016/S1773-035X(09)70313-2. Epub 2009 Dec 11.
Antiviral research is a recent discipline and the number of molecules available to fight against viral infections remains still insufficient. However, both diseases caused by emerging endemic viruses and the existence of resistance from some viruses against antiviral make necessary a constant search for new antiviral drugs. Parallel to the development of traditional molecules such as nucleoside analogues, whose effectiveness is well demonstrated, pharmaceutical industry is now turning to new solutions such as antiviral peptides, which constitute a new exploration field in therapy. The recent progress in disciplines such as genomics, proteomics and structural biology have improved our fundamental understanding of the viral world. These advances can be used to efficiently create new drugs more selective and more effective. Identification and development of these molecules require the use of newer techniques such as high-throughput screening of combinatorial compound libraries and the use of new bioinformatics tools. This review aims to present some recent methods for the development of antiviral molecules.
抗病毒研究是一门新兴学科，可用于对抗病毒感染的分子数量仍然不足。然而，由新出现的地方性病毒引起的疾病以及一些病毒对抗病毒药物产生的耐药性，使得持续寻找新的抗病毒药物成为必要。在核苷类似物等传统分子的研发取得显著成效的同时，制药行业目前正转向新的解决方案，如抗病毒肽，这构成了治疗领域的一个新探索方向。基因组学、蛋白质组学和结构生物学等学科的最新进展，加深了我们对病毒世界的基本认识。这些进展可用于高效开发更具选择性和更有效的新药。这些分子的鉴定和开发需要使用更新的技术，如组合化合物库的高通量筛选以及新的生物信息学工具。本综述旨在介绍一些抗病毒分子开发的最新方法。
