Krautkrämer E, Zeier M
Nephrologie, Universitätsklinik Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Deutschland.
Nephrologe. 2008;3(1):8-13. doi: 10.1007/s11560-007-0125-8. Epub 2007 Nov 28.
Among the emerging viruses, hantaviruses are being focused on more and more due to their increasing number and worldwide distribution. Transmission occurs via inhalation of aerosolized infected rodent excreta. The symptoms and course of disease vary with the infecting hantavirus species. The distribution of the different hantavirus species correlates with the geographical distribution of the virus-type-specific rodent host. Hantaviruses in Europe and Asia cause hemorrhagic fever with renal syndrome (HFRS). Infection with Puumala, the prevalent virus type in Germany, results in a more moderate form of HFRS, nephropathia epidemica. Infections with virus species on the American continents lead to a clinical picture with predominantly pulmonary pathology (hantaviral pulmonary syndrome). No specific antiviral therapy or approved vaccines are available for any hantavirus species. Controlling the rodent populations and avoiding contact with rodent excrement are the only measures that can be undertaken to contain and prevent infection.
在新兴病毒中,汉坦病毒因其数量不断增加且分布于全球而越来越受到关注。传播途径是吸入雾化的受感染啮齿动物排泄物。疾病的症状和病程因感染的汉坦病毒种类而异。不同汉坦病毒种类的分布与病毒型特异性啮齿动物宿主的地理分布相关。欧洲和亚洲的汉坦病毒可引起肾综合征出血热(HFRS)。感染德国流行的普马拉病毒会导致症状较轻的肾综合征出血热,即流行性肾病。美洲大陆的病毒种类感染会导致以肺部病理为主的临床表现(汉坦病毒肺综合征)。目前尚无针对任何汉坦病毒种类的特异性抗病毒疗法或获批疫苗。控制啮齿动物数量并避免接触啮齿动物粪便,是能够采取的控制和预防感染的唯一措施。