急性肝衰竭的管理：儿科视角
Management of Acute Liver Failure: A Pediatric Perspective.
作者信息
Bhatt Heli, Rao Girish S
机构信息
Section of Pediatric Gastroenterology, Hepatology and Nutrition, Riley Hospital for Children, Indiana University School of Medicine, Indiana University, 705 Riley Hospital Drive, ROC 4210, Indianapolis, IN 46202 USA.
出版信息
Curr Pediatr Rep. 2018;6(3):246-257. doi: 10.1007/s40124-018-0174-7. Epub 2018 May 15.
PURPOSE OF REVIEW
Pediatric acute liver failure is a rare, complex, rapidly progressing, and life-threatening illness. Majority of pediatric acute liver failures have unknown etiology. This review intends to discuss the current literature on the challenging aspects of management of acute liver failure.
RECENT FINDINGS
Collaborative multidisciplinary approach for management of patients with pediatric acute liver failure with upfront involvement of transplant hepatologist and critical care specialists can improve outcomes of this fatal disease. Extensive but systematic diagnostic evaluation can help to identify etiology and guide management. Early referral to a transplant center with prompt liver transplant, if indicated, can lead to improved survival in these patients.
SUMMARY
Prompt identification and aggressive management of pediatric acute liver failure and related comorbidities can lead to increased transplant-free survival and improved post-transplant outcomes, thus decreasing mortality and morbidity associated with this potential fatal condition.
综述目的
儿童急性肝衰竭是一种罕见、复杂、进展迅速且危及生命的疾病。大多数儿童急性肝衰竭病因不明。本综述旨在讨论当前关于急性肝衰竭管理中具有挑战性方面的文献。
最新发现
对于儿童急性肝衰竭患者，采用多学科协作方法，由移植肝病专家和重症监护专家早期介入进行管理，可改善这种致命疾病的治疗结果。广泛但系统的诊断评估有助于确定病因并指导治疗。如果有指征，早期转诊至移植中心并及时进行肝移植，可提高这些患者的生存率。
总结
及时识别并积极管理儿童急性肝衰竭及其相关合并症，可提高无移植生存率并改善移植后结局，从而降低与这种潜在致命疾病相关的死亡率和发病率。
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