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奈他地尔相关的结膜色素沉着。

Netarsudil-associated conjunctival pigmentation.

作者信息

Azargui Soufiane, Karanxha Joana, Oliver Scott Cn, Kahook Malik Y, Capitena Young Cara E

机构信息

Department of Ophthalmology, University of Colorado School of Medicine, Sue Anschutz-Rodgers Eye Center, Aurora, Colorado, USA.

出版信息

Am J Ophthalmol Case Rep. 2025 Mar 25;38:102311. doi: 10.1016/j.ajoc.2025.102311. eCollection 2025 Jun.

DOI:10.1016/j.ajoc.2025.102311
PMID:40236508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11998109/
Abstract

PURPOSE

To present a case of conjunctival pigmentation associated with topical use of netarsudil 0.02 % (Rhopressa, Alcon, Fort Worth, TX).

OBSERVATION

Bilateral conjunctival pigmentation and cornea verticillata developed after 21 months of initiating netarsudil treatment. The appearance of the conjunctival pigmentation mimicked primary acquired melanosis. Both the conjunctival and corneal findings resolved 14 months after stopping the medication.

CONCLUSION

While the correlation between netarsudil use and corneal verticillata is well-established, we could not identify prior reports of such an association with conjunctival pigmentation. Eye care professionals prescribing netarsudil should be aware of this potential sequela of therapy.

摘要

目的

报告一例与局部使用0.02%奈他地尔（Rhopressa，爱尔康公司，得克萨斯州沃思堡）相关的结膜色素沉着病例。

观察结果

开始使用奈他地尔治疗21个月后出现双侧结膜色素沉着和角膜涡状浑浊。结膜色素沉着的外观类似原发性获得性黑素沉着症。停药14个月后，结膜和角膜的病变均消退。

结论

虽然奈他地尔使用与角膜涡状浑浊之间的相关性已得到充分证实，但我们未发现此前有关于这种药物与结膜色素沉着相关的报道。开具奈他地尔处方的眼科护理专业人员应了解这种潜在的治疗后遗症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/be98625817ca/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/d3ccce6a1039/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/d3135d38e4d7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/e7ec798d457b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/62f514b83503/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/68c7d467a059/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/df0f7fcd481c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/be98625817ca/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/d3ccce6a1039/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/d3135d38e4d7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/e7ec798d457b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/62f514b83503/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/68c7d467a059/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/df0f7fcd481c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a08/11998109/be98625817ca/gr7.jpg

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本文引用的文献

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Crystalline keratopathy following long-term netarsudil therapy.长期使用奈他地尔治疗后的结晶性角膜病变。
Am J Ophthalmol Case Rep. 2024 May 3;35:102069. doi: 10.1016/j.ajoc.2024.102069. eCollection 2024 Sep.
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Rhopressa-induced corneal edema: a case report.罗普雷斯诱导的角膜水肿：一例报告。
J Med Case Rep. 2021 Apr 2;15(1):182. doi: 10.1186/s13256-021-02665-0.
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