Department of Geriatric Respiratory and Critical Care, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui 230022, PR China; Fuyang Infectious Disease Clinical College of Anhui Medical University, Yingzhou west Road 1088, Fuyang, Anhui 236015, PR China; Department of Respiratory and Critical Care, the Second People's Hospital of Fuyang City, Yingzhou west Road 1088, Fuyang, Anhui 236015, PR China.
Department of Geriatric Respiratory and Critical Care, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui 230022, PR China; Anhui Geriatric Institute, Jixi Road 218, Hefei, Anhui 230022, PR China; Institute of Respiratory Diseases, Anhui Medical University, Jixi Road 218, Hefei, Anhui 230022, PR China.
Int J Infect Dis. 2020 Jun;95:421-428. doi: 10.1016/j.ijid.2020.03.070. Epub 2020 Apr 11.
To investigate the epidemiological and clinical features of patients with COVID-19 in Anhui province of China.
In this descriptive study, we obtained epidemiological, demographic, manifestations, laboratory data and radiological findings of patients confirmed by real-time RT-PCR in the NO.2 People's Hospital of Fuyang City from Jan 20 to Feb 9, 2020. Clinical outcomes were followed up to Feb 18, 2020.
Of 125 patients infected SARS-CoV-2, the mean age was 38.76 years (SD, 13.799) and 71(56.8%) were male. Common symptoms include fever [116 (92.8%)], cough [102(81.6%)], and shortness of breath [57(45.6%)]. Lymphocytopenia developed in 48(38.4%) patients. 100(80.0%) patients showed bilateral pneumonia, 26(20.8%) patients showed multiple mottling and ground-glass opacity. All patients were given antiviral therapy. 19(15.2%) patients were transferred to the intensive care unit. By February 18, 47(37.6%) patients were discharged and none of patients died. Among the discharged patients, the median time of length of stay was 14.8 days (SD 4.16).
In this single-center, retrospective, descriptive study, fever is the most common symptom. Old age, chronic underlying diseases and smoking history may be risk factors to worse condition. Certain laboratory inspection may contribute to the judgment of the severity of illness.
调查中国安徽省 COVID-19 患者的流行病学和临床特征。
在这项描述性研究中，我们获取了 2020 年 1 月 20 日至 2 月 9 日阜阳市第二人民医院通过实时 RT-PCR 确诊的患者的流行病学、人口统计学、临床表现、实验室数据和影像学结果。临床结局随访至 2020 年 2 月 18 日。
在 125 例感染 SARS-CoV-2 的患者中，平均年龄为 38.76 岁（标准差 13.799），71 例（56.8%）为男性。常见症状包括发热[116 例（92.8%）]、咳嗽[102 例（81.6%）]和呼吸急促[57 例（45.6%）]。48 例（38.4%）患者出现淋巴细胞减少症。100 例（80.0%）患者表现为双侧肺炎，26 例（20.8%）患者表现为多发性斑驳和磨玻璃影。所有患者均接受抗病毒治疗。19 例（15.2%）患者转入重症监护病房。截至 2 月 18 日，47 例（37.6%）患者出院，无患者死亡。在出院患者中，中位住院时间为 14.8 天（标准差 4.16）。
在这项单中心、回顾性、描述性研究中，发热是最常见的症状。高龄、慢性基础疾病和吸烟史可能是病情恶化的危险因素。某些实验室检查可能有助于判断疾病严重程度。
