Ryu H J, Park J-H, Choi M, Jung J-H, Han K, Kwon D-Y, Kim D-H, Park Y-G
Department of Dermatology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
Department of Family Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
J Eur Acad Dermatol Venereol. 2020 Dec;34(12):2775-2780. doi: 10.1111/jdv.16462. Epub 2020 May 13.
Previous studies have reported that patients with Parkinson's disease (PD) have a significantly lower risk of cancer. Studies reporting prevalence of skin cancers in Parkinson's disease mostly involve Caucasians.
A nationwide population-based study was conducted to determine the risk of skin cancer in patients diagnosed with PD in Korea.
Data obtained from National Health Insurance Claims records were used to retrieve information about 70 780 patients with newly diagnosed PD between January 2010 and December 2015. The control group included 353 900 sex- and age-matched patients without PD. In this nationwide population-based cohort study, we investigated the association between PD and skin cancer.
The overall hazard ratio (HR) of skin cancers in patients with PD was 1.169 (95% CI, 1.005-1.359) compared with non-PD group. Among patients with PD, males aged above 65 had a 2.8-fold increase in the risk for melanoma development than the non-PD group (HR, 2.825; 95% CI, 1.395-5.721). In addition, female PD patients aged above 65 years showed a 1.3-fold increase in non-melanoma skin cancer risk than the non-PD group (HR, 1.305; 95% 1.073-1.589).
Compared with the general population, Korean patients diagnosed with PD had a greater risk of skin cancer. Especially, male patients aged 65 years and above, and diagnosed with PD had a significant risk of melanoma development compared with control.
既往研究报道帕金森病（PD）患者患癌风险显著降低。报告帕金森病皮肤癌患病率的研究大多涉及白种人。
开展一项基于全国人群的研究，以确定韩国确诊为PD的患者患皮肤癌的风险。
利用从国民健康保险理赔记录中获取的数据，检索2010年1月至2015年12月期间70780例新诊断为PD的患者的信息。对照组包括353900例年龄和性别匹配的非PD患者。在这项基于全国人群的队列研究中，我们调查了PD与皮肤癌之间的关联。
与非PD组相比，PD患者皮肤癌的总体风险比（HR）为1.169（95%CI，1.005 - 1.359）。在PD患者中，65岁以上男性患黑色素瘤的风险比非PD组增加2.8倍（HR，2.825；95%CI，1.395 - 5.721）。此外，65岁以上的女性PD患者患非黑色素瘤皮肤癌的风险比非PD组增加1.3倍（HR，1.305；95%CI，1.073 - 1.589）。
与普通人群相比，韩国确诊为PD的患者患皮肤癌的风险更高。特别是，65岁及以上且确诊为PD的男性患者与对照组相比，患黑色素瘤的风险显著增加。
