Lee Il Hwan, Kim Dong-Kyu
Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
Institute of New Frontier Research, Division of Big Data and Artificial Intelligence, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea.
Cancers (Basel). 2024 Jul 8;16(13):2486. doi: 10.3390/cancers16132486.
Head and neck cancers (HNC) are frequently associated with neurodegeneration. However, the association between HNC and Parkinson's disease (PD) remains unclear. This study aimed to clarify the relationship between HNC and subsequent PD. This retrospective study used data from a nationally representative cohort. Patients with HNC were identified based on the presence of corresponding diagnostic codes. Participants without cancer were selected using 4:1 propensity score matching based on sociodemographic factors and year of enrollment; 2296 individuals without HNC and 574 individuals with HNC were included in the study. Hazard ratios (HR) for the incidence of PD in patients with HNC were calculated using 95% confidence intervals (CI). The incidence of PD was 4.17 and 2.18 per 1000 person-years in the HNC and control groups, respectively (adjusted HR = 1.89, 95% CI = 1.08-3.33). The HNC group also showed an increased risk of subsequent PD development. The risk of PD was higher in middle-aged (55-69 years) patients with HNC and oral cavity cancer. Our findings suggest that middle-aged patients with HNC have an increased incidence of PD, specifically those with oral cavity cancer. Therefore, our findings provide new insights into the development of PD in patients with HNC.
头颈癌（HNC）常与神经退行性变相关。然而，HNC与帕金森病（PD）之间的关联仍不明确。本研究旨在阐明HNC与后续发生PD之间的关系。这项回顾性研究使用了来自全国代表性队列的数据。根据相应诊断编码确定HNC患者。基于社会人口统计学因素和入组年份，采用4:1倾向评分匹配法选择无癌症的参与者；2296名无HNC个体和574名HNC个体纳入本研究。使用95%置信区间（CI）计算HNC患者中PD发病的风险比（HR）。HNC组和对照组中PD的发病率分别为每1000人年4.17例和2.18例（调整后HR = 1.89，95%CI = 1.08 - 3.33）。HNC组后续发生PD的风险也有所增加。中年（55 - 69岁）HNC患者和口腔癌患者发生PD的风险更高。我们的研究结果表明，中年HNC患者，尤其是口腔癌患者，发生PD的发病率增加。因此，我们的研究结果为HNC患者发生PD的情况提供了新的见解。
